GLDN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0045162Biological processclustering of voltage-gated sodium channels
GO_0032528Biological processmicrovillus organization
GO_0034113Biological processheterotypic cell-cell adhesion
GO_0005615Cellular componentextracellular space
GO_0009986Cellular componentcell surface
GO_0030424Cellular componentaxon
GO_0005581Cellular componentcollagen trimer
GO_0005886Cellular componentplasma membrane
GO_0086080Molecular functionprotein binding involved in heterotypic cell-cell adhesion

IV. Literature review

[source]
Gene nameGLDN
Protein nameGliomedin [Cleaved into: Gliomedin shedded ectodomain]
Gliomedin
GLDN protein
SynonymsUNQ9339/PRO34011
COLM
DescriptionFUNCTION: Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. .

AccessionsENST00000396399.6 [Q6ZMI3-2]
ENST00000560215.5
Q6ZMI3
H0YM22
Q14DE1
A0A087X220
ENST00000558426.5
ENST00000335449.11 [Q6ZMI3-1]