Name | Number of supported studies | Average coverage | |
---|---|---|---|
classical monocyte | 16 studies | 26% ± 9% | |
macrophage | 11 studies | 21% ± 5% | |
regulatory T cell | 8 studies | 17% ± 1% | |
monocyte | 7 studies | 25% ± 5% | |
conventional dendritic cell | 6 studies | 22% ± 7% | |
non-classical monocyte | 6 studies | 23% ± 7% | |
epithelial cell | 5 studies | 30% ± 7% | |
squamous epithelial cell | 4 studies | 40% ± 16% | |
endothelial cell | 4 studies | 18% ± 2% | |
myeloid cell | 4 studies | 28% ± 5% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 17% ± 1% | |
neutrophil | 3 studies | 24% ± 6% | |
ciliated cell | 3 studies | 25% ± 8% | |
abnormal cell | 3 studies | 20% ± 4% | |
type II pneumocyte | 3 studies | 22% ± 6% | |
GABAergic neuron | 3 studies | 38% ± 10% | |
glutamatergic neuron | 3 studies | 40% ± 17% | |
alveolar macrophage | 3 studies | 25% ± 9% | |
astrocyte | 3 studies | 24% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
liver | 100% | 4514.83 | 226 / 226 | 100% | 52.94 | 406 / 406 |
uterus | 100% | 3376.03 | 170 / 170 | 100% | 39.35 | 459 / 459 |
thymus | 100% | 3770.67 | 652 / 653 | 100% | 43.39 | 605 / 605 |
skin | 100% | 6948.56 | 1809 / 1809 | 100% | 52.90 | 471 / 472 |
lung | 100% | 5260.41 | 577 / 578 | 100% | 39.84 | 1154 / 1155 |
esophagus | 100% | 4594.17 | 1441 / 1445 | 100% | 26.44 | 183 / 183 |
kidney | 100% | 4250.01 | 89 / 89 | 100% | 42.27 | 898 / 901 |
breast | 100% | 4257.24 | 459 / 459 | 99% | 37.68 | 1109 / 1118 |
prostate | 100% | 3649.90 | 244 / 245 | 100% | 47.31 | 500 / 502 |
adrenal gland | 100% | 6346.51 | 258 / 258 | 99% | 48.35 | 228 / 230 |
intestine | 100% | 2671.79 | 966 / 966 | 99% | 29.16 | 522 / 527 |
stomach | 99% | 2078.66 | 356 / 359 | 99% | 26.53 | 283 / 286 |
bladder | 100% | 2535.57 | 21 / 21 | 98% | 31.77 | 494 / 504 |
brain | 98% | 2881.41 | 2582 / 2642 | 100% | 37.75 | 705 / 705 |
ovary | 100% | 2655.39 | 180 / 180 | 95% | 17.22 | 407 / 430 |
pancreas | 88% | 1452.00 | 290 / 328 | 100% | 45.98 | 178 / 178 |
adipose | 100% | 4084.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 62.47 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 43.43 | 29 / 29 |
muscle | 100% | 14131.56 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3614.54 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 37.99 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 19.34 | 1 / 1 |
blood vessel | 99% | 2871.44 | 1328 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 98% | 8015.65 | 913 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 3833.50 | 833 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006897 | Biological process | endocytosis |
GO_0061909 | Biological process | autophagosome-lysosome fusion |
GO_1904978 | Biological process | regulation of endosome organization |
GO_0007165 | Biological process | signal transduction |
GO_0016197 | Biological process | endosomal transport |
GO_0015031 | Biological process | protein transport |
GO_1901098 | Biological process | positive regulation of autophagosome maturation |
GO_0061753 | Biological process | substrate localization to autophagosome |
GO_0035579 | Cellular component | specific granule membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0016020 | Cellular component | membrane |
GO_0005769 | Cellular component | early endosome |
GO_0031901 | Cellular component | early endosome membrane |
GO_0035577 | Cellular component | azurophil granule membrane |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0010008 | Cellular component | endosome membrane |
GO_0005768 | Cellular component | endosome |
GO_0032050 | Molecular function | clathrin heavy chain binding |
GO_0030276 | Molecular function | clathrin binding |
GO_0031593 | Molecular function | polyubiquitin modification-dependent protein binding |
GO_0070853 | Molecular function | myosin VI binding |
GO_0005515 | Molecular function | protein binding |
GO_0010314 | Molecular function | phosphatidylinositol-5-phosphate binding |
GO_0043130 | Molecular function | ubiquitin binding |
Gene name | TOM1 |
Protein name | Target of Myb1 membrane trafficking protein (Target of Myb protein 1) Target of myb1 membrane trafficking protein Target of myb1 (Chicken), isoform CRA_a (cDNA FLJ40607 fis, clone THYMU2012273, highly similar to Target of Myb protein 1) |
Synonyms | hCG_41524 |
Description | FUNCTION: Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways . Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures . Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes . MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN . Binds to polyubiquitinated proteins via its GAT domain . In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes . The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin . Mediates clathrin recruitment to early endosomes by ZFYVE16 . Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking . Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation . PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation . Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling . . |
Accessions | B3KUU1 ENST00000608749.5 ENST00000411850.5 [O60784-2] V9GZ68 ENST00000449508.1 ENST00000456128.5 F8WBB0 ENST00000439512.5 ENST00000404284.6 B0QY02 H7BYN7 F8WAW7 F8WB30 F8WE29 ENST00000443206.2 ENST00000424387.5 ENST00000447733.5 [O60784-4] O60784 ENST00000608674.5 ENST00000395736.7 ENST00000449058.7 [O60784-1] ENST00000425375.5 [O60784-3] V9GYF4 B0QY01 |