TOM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0061909Biological processautophagosome-lysosome fusion
GO_1904978Biological processregulation of endosome organization
GO_0007165Biological processsignal transduction
GO_0016197Biological processendosomal transport
GO_0015031Biological processprotein transport
GO_1901098Biological processpositive regulation of autophagosome maturation
GO_0061753Biological processsubstrate localization to autophagosome
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0035577Cellular componentazurophil granule membrane
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0032050Molecular functionclathrin heavy chain binding
GO_0030276Molecular functionclathrin binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0070853Molecular functionmyosin VI binding
GO_0005515Molecular functionprotein binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameTOM1
Protein nameTarget of Myb1 membrane trafficking protein (Target of Myb protein 1)
Target of myb1 membrane trafficking protein
Target of myb1 (Chicken), isoform CRA_a (cDNA FLJ40607 fis, clone THYMU2012273, highly similar to Target of Myb protein 1)
SynonymshCG_41524
DescriptionFUNCTION: Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways . Acts as a MYO6/Myosin VI adapter protein that targets MYO6 to endocytic structures . Together with MYO6, required for autophagosomal delivery of endocytic cargo, the maturation of autophagosomes and their fusion with lysosomes . MYO6 links TOM1 with autophagy receptors, such as TAX1BP1; CALCOCO2/NDP52 and OPTN . Binds to polyubiquitinated proteins via its GAT domain . In a complex with TOLLIP, recruits ubiquitin-conjugated proteins onto early endosomes . The Tom1-Tollip complex may regulate endosomal trafficking by linking polyubiquitinated proteins to clathrin . Mediates clathrin recruitment to early endosomes by ZFYVE16 . Modulates binding of TOLLIP to phosphatidylinositol 3-phosphate (PtdIns(3)P) via binding competition; the association with TOLLIP may favor the release of TOLLIP from endosomal membranes, allowing TOLLIP to commit to cargo trafficking . Acts as a phosphatidylinositol 5-phosphate (PtdIns(5)P) effector by binding to PtdIns(5)P, thereby regulating endosomal maturation . PtdIns(5)P-dependent recruitment to signaling endosomes may block endosomal maturation . Also inhibits Toll-like receptor (TLR) signaling and participates in immune receptor recycling . .

AccessionsB3KUU1
ENST00000608749.5
ENST00000411850.5 [O60784-2]
V9GZ68
ENST00000449508.1
ENST00000456128.5
F8WBB0
ENST00000439512.5
ENST00000404284.6
B0QY02
H7BYN7
F8WAW7
F8WB30
F8WE29
ENST00000443206.2
ENST00000424387.5
ENST00000447733.5 [O60784-4]
O60784
ENST00000608674.5
ENST00000395736.7
ENST00000449058.7 [O60784-1]
ENST00000425375.5 [O60784-3]
V9GYF4
B0QY01