GRB14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0008286Biological processinsulin receptor signaling pathway
GO_0046627Biological processnegative regulation of insulin receptor signaling pathway
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005737Cellular componentcytoplasm
GO_0060090Molecular functionmolecular adaptor activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding

IV. Literature review

[source]
Gene nameGRB14
Protein nameUncharacterized protein GRB14
Growth factor receptor bound protein 14
Growth factor receptor-bound protein 14 (GRB14 adapter protein)
Synonyms
DescriptionFUNCTION: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. .

AccessionsENST00000263915.8 [Q14449-1]
ENST00000446413.6
Q53QM9
Q53QQ0
C9JD37
Q14449
C9JLT6
ENST00000696453.2 [Q14449-2]
ENST00000424693.1