ARAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001921Biological processpositive regulation of receptor recycling
GO_0043547Biological processpositive regulation of GTPase activity
GO_0007165Biological processsignal transduction
GO_0051056Biological processregulation of small GTPase mediated signal transduction
GO_0051491Biological processpositive regulation of filopodium assembly
GO_0007015Biological processactin filament organization
GO_0008360Biological processregulation of cell shape
GO_0051497Biological processnegative regulation of stress fiber assembly
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005802Cellular componenttrans-Golgi network
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0032580Cellular componentGolgi cisterna membrane
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0031702Molecular functiontype 1 angiotensin receptor binding
GO_0005096Molecular functionGTPase activator activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARAP1
Protein nameARAP1 protein
ARAP1
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Centaurin-delta-2) (Cnt-d2)
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
SynonymsCENTD2
KIAA0782
DescriptionFUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5 (By similarity). .

AccessionsF5GWN4
A0A2X0SFK3
F8WBT0
ENST00000427971.6
ENST00000393609.8 [Q96P48-6]
Q96P48
ENST00000536885.1
ENST00000393605.7 [Q96P48-1]
ENST00000426523.5
ENST00000334211.12 [Q96P48-4]
F5GWQ2
ENST00000429686.5 [Q96P48-7]
E7EU13
B7ZMI2
ENST00000542596.5
ENST00000452383.2
H0YGD1
ENST00000359373.9 [Q96P48-3]