SIGIRR report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	32% ± 10%	Explore
CD8-positive, alpha-beta T cell	28 studies	29% ± 10%	Explore
CD4-positive, alpha-beta T cell	26 studies	30% ± 10%	Explore
endothelial cell	22 studies	26% ± 10%	Explore
T cell	19 studies	26% ± 6%	Explore
regulatory T cell	18 studies	28% ± 8%	Explore
mature NK T cell	17 studies	32% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	39% ± 12%	Explore
ciliated cell	15 studies	32% ± 13%	Explore
gamma-delta T cell	15 studies	31% ± 9%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	35% ± 10%	Explore
classical monocyte	12 studies	26% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	24% ± 9%	Explore
non-classical monocyte	11 studies	28% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	32% ± 6%	Explore
mucosal invariant T cell	10 studies	29% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	33% ± 6%	Explore
capillary endothelial cell	9 studies	22% ± 7%	Explore
endothelial cell of artery	9 studies	23% ± 4%	Explore
endothelial cell of lymphatic vessel	8 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	33% ± 11%	Explore
vein endothelial cell	8 studies	21% ± 7%	Explore
B cell	7 studies	18% ± 2%	Explore
epithelial cell	7 studies	35% ± 14%	Explore
T follicular helper cell	7 studies	27% ± 6%	Explore
monocyte	6 studies	17% ± 1%	Explore
pericyte	6 studies	18% ± 3%	Explore
basal cell	5 studies	26% ± 11%	Explore
exhausted T cell	5 studies	33% ± 12%	Explore
epithelial cell of proximal tubule	5 studies	31% ± 10%	Explore
fibroblast	5 studies	26% ± 7%	Explore
goblet cell	5 studies	24% ± 9%	Explore
conventional dendritic cell	4 studies	37% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	28% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	35% ± 13%	Explore
innate lymphoid cell	4 studies	30% ± 11%	Explore
brush cell	4 studies	29% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	32% ± 8%	Explore
memory B cell	4 studies	20% ± 3%	Explore
secretory cell	3 studies	26% ± 11%	Explore
myofibroblast cell	3 studies	17% ± 1%	Explore
smooth muscle cell	3 studies	18% ± 1%	Explore
abnormal cell	3 studies	21% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	29% ± 8%	Explore
endothelial cell of vascular tree	3 studies	24% ± 2%	Explore
CD4-positive helper T cell	3 studies	21% ± 8%	Explore
neuron	3 studies	31% ± 16%	Explore
macrophage	3 studies	20% ± 2%	Explore
dendritic cell	3 studies	37% ± 14%	Explore
enteroendocrine cell	3 studies	29% ± 9%	Explore
T-helper 17 cell	3 studies	21% ± 2%	Explore
double negative thymocyte	3 studies	36% ± 4%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	30% ± 6%	Explore
lung	7 studies	22% ± 9%	Explore
kidney	4 studies	23% ± 2%	Explore
intestine	4 studies	21% ± 8%	Explore
liver	4 studies	22% ± 3%	Explore
lymph node	3 studies	22% ± 4%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	100%	2653.42	359 / 359	100%	46.34	285 / 286
intestine	100%	3382.46	966 / 966	100%	51.93	525 / 527
pancreas	100%	2126.84	328 / 328	99%	49.59	177 / 178
prostate	100%	3316.36	245 / 245	99%	52.13	499 / 502
thymus	100%	3090.03	653 / 653	99%	41.21	601 / 605
breast	100%	2225.44	459 / 459	97%	48.95	1090 / 1118
lung	100%	3202.03	578 / 578	97%	33.34	1116 / 1155
ovary	97%	981.12	174 / 180	100%	49.64	428 / 430
bladder	100%	2163.10	21 / 21	96%	38.86	483 / 504
kidney	100%	5355.94	89 / 89	95%	28.35	857 / 901
liver	100%	4425.33	226 / 226	95%	40.82	386 / 406
uterus	100%	2021.81	170 / 170	94%	37.34	433 / 459
skin	97%	868.65	1758 / 1809	96%	35.21	453 / 472
esophagus	100%	1735.74	1445 / 1445	91%	26.71	166 / 183
brain	86%	1044.52	2284 / 2642	41%	5.48	288 / 705
adrenal gland	87%	585.82	225 / 258	29%	5.32	67 / 230
eye	0%	0	0 / 0	100%	76.41	80 / 80
lymph node	0%	0	0 / 0	100%	38.22	29 / 29
spleen	100%	6902.20	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	56.66	1 / 1
adipose	100%	1872.32	1203 / 1204	0%	0	0 / 0
heart	99%	1290.55	856 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	32.83	44 / 45
blood vessel	95%	1056.99	1267 / 1335	0%	0	0 / 0
peripheral blood	92%	3364.48	858 / 929	0%	0	0 / 0
muscle	32%	165.43	254 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0