APPL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0099558Biological processmaintenance of synapse structure
GO_0046326Biological processpositive regulation of glucose import
GO_1905450Biological processnegative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO_0007165Biological processsignal transduction
GO_0033211Biological processadiponectin-activated signaling pathway
GO_0035729Biological processcellular response to hepatocyte growth factor stimulus
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_1905303Biological processpositive regulation of macropinocytosis
GO_1900017Biological processpositive regulation of cytokine production involved in inflammatory response
GO_0045088Biological processregulation of innate immune response
GO_0008286Biological processinsulin receptor signaling pathway
GO_0006606Biological processprotein import into nucleus
GO_0048023Biological processpositive regulation of melanin biosynthetic process
GO_0010762Biological processregulation of fibroblast migration
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0034143Biological processregulation of toll-like receptor 4 signaling pathway
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0046324Biological processregulation of glucose import
GO_0023052Biological processsignaling
GO_0001726Cellular componentruffle
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0012506Cellular componentvesicle membrane
GO_0032009Cellular componentearly phagosome
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0044354Cellular componentmacropinosome
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0098794Cellular componentpostsynapse
GO_0097708Cellular componentintracellular vesicle
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0048487Molecular functionbeta-tubulin binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0043422Molecular functionprotein kinase B binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPPL1
Protein nameDCC-interacting protein 13-alpha (Dip13-alpha) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 1)
Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
SynonymsAPPL
DIP13A
KIAA1428
DescriptionFUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism . Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex . Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages (By similarity). Regulates TLR4 signaling in activated macrophages (By similarity). Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner . Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways . Required for fibroblast migration through HGF cell signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex . .

AccessionsC9K0C4
ENST00000288266.8
ENST00000495803.5
ENST00000444459.1
C9JAB0
ENST00000650354.1
Q9UKG1