REG3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006953Biological processacute-phase response
GO_0043434Biological processresponse to peptide hormone
GO_0007165Biological processsignal transduction
GO_0010838Biological processpositive regulation of keratinocyte proliferation
GO_0009609Biological processresponse to symbiotic bacterium
GO_0045617Biological processnegative regulation of keratinocyte differentiation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0106015Biological processnegative regulation of inflammatory response to wounding
GO_2000972Biological processpositive regulation of detection of glucose
GO_0009611Biological processresponse to wounding
GO_0007157Biological processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
GO_0090303Biological processpositive regulation of wound healing
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0038023Molecular functionsignaling receptor activity
GO_0042834Molecular functionpeptidoglycan binding
GO_0005179Molecular functionhormone activity
GO_0030246Molecular functioncarbohydrate binding
GO_0042802Molecular functionidentical protein binding
GO_0070492Molecular functionoligosaccharide binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameREG3A
Protein nameRegenerating family member 3 alpha
Alternative protein REG3A
Regenerating islet-derived protein 3-alpha (REG-3-alpha) (Hepatointestinal pancreatic protein) (HIP/PAP) (Human proislet peptide) (HIP) (Pancreatitis-associated protein 1) (Regenerating islet-derived protein III-alpha) (Reg III-alpha) [Cleaved into: Regenerating islet-derived protein 3-alpha 16.5 kDa form; Regenerating islet-derived protein 3-alpha 15 kDa form]
Proliferation-inducing protein 34 (Proliferation-inducing protein 42) (Regenerating islet-derived 3 alpha, isoform CRA_a) (cDNA FLJ76569, highly similar to Homo sapiens regenerating islet-derived 3 alpha (REG3A), transcript variant 1, mRNA)
SynonymshCG_39519
PAP
HIP
PAP1
DescriptionFUNCTION: [Regenerating islet-derived protein 3-alpha 15 kDa form]: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan . Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore . .; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways . Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway . In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF . In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation . .; FUNCTION: [Regenerating islet-derived protein 3-alpha 16.5 kDa form]: Has bacteriostatic activity. .

AccessionsA0A669KAZ1
ENST00000393878.5
Q06141
ENST00000305165.3
ENST00000490901.2
ENST00000409839.7
Q53S56
L8E7R5