AKAP10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0008104Biological processprotein localization
GO_0032991Cellular componentprotein-containing complex
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005739Cellular componentmitochondrion
GO_0051018Molecular functionprotein kinase A binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAKAP10
Protein nameA kinase anchor protein 10 isoform 2
A kinase anchor protein 10 isoform 1
A kinase anchor protein 10 isoform 4
A-kinase anchoring protein 10
A kinase anchor protein 10 isoform 3
A-kinase anchor protein 10, mitochondrial (AKAP-10) (Dual specificity A kinase-anchoring protein 2) (D-AKAP-2) (Protein kinase A-anchoring protein 10) (PRKA10)
A kinase anchor protein 10 isoform 5
Synonyms
DescriptionFUNCTION: Differentially targeted protein that binds to type I and II regulatory subunits of protein kinase A and anchors them to the mitochondria or the plasma membrane. Although the physiological relevance between PKA and AKAPS with mitochondria is not fully understood, one idea is that BAD, a proapoptotic member, is phosphorylated and inactivated by mitochondria-anchored PKA. It cannot be excluded too that it may facilitate PKA as well as G protein signal transduction, by acting as an adapter for assembling multiprotein complexes. With its RGS domain, it could lead to the interaction to G-alpha proteins, providing a link between the signaling machinery and the downstream kinase (By similarity). .

AccessionsENST00000572341.5
ENST00000225737.11
J3QRM7
A0A0S2Z4Z7
ENST00000571858.1
A0A0S2Z5A1
ENST00000583951.1
I3L479
A0A0S2Z551
ENST00000576896.5
ENST00000578898.1
ENST00000460046.2
I3L177
K7EM25
J3QL61
J3QR74
ENST00000582611.5
E7EMD6
ENST00000395536.7
A0A0S2Z4Y8
A0A0S2Z513
O43572
I3NI04