DOK2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	41% ± 13%	Explore
CD8-positive, alpha-beta T cell	26 studies	30% ± 11%	Explore
macrophage	24 studies	31% ± 11%	Explore
CD4-positive, alpha-beta T cell	24 studies	25% ± 7%	Explore
non-classical monocyte	23 studies	43% ± 15%	Explore
regulatory T cell	23 studies	36% ± 13%	Explore
T cell	22 studies	28% ± 9%	Explore
classical monocyte	22 studies	32% ± 12%	Explore
conventional dendritic cell	21 studies	28% ± 15%	Explore
mature NK T cell	20 studies	33% ± 11%	Explore
monocyte	19 studies	27% ± 8%	Explore
gamma-delta T cell	16 studies	33% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	38% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	50% ± 11%	Explore
dendritic cell	11 studies	28% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	30% ± 14%	Explore
platelet	9 studies	32% ± 9%	Explore
mucosal invariant T cell	9 studies	23% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	32% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	33% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	32% ± 16%	Explore
alveolar macrophage	6 studies	36% ± 7%	Explore
leukocyte	6 studies	24% ± 5%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	19% ± 3%	Explore
innate lymphoid cell	5 studies	32% ± 9%	Explore
myeloid cell	5 studies	28% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	46% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	36% ± 16%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	27% ± 9%	Explore
mononuclear phagocyte	4 studies	35% ± 8%	Explore
exhausted T cell	4 studies	46% ± 15%	Explore
megakaryocyte	4 studies	35% ± 13%	Explore
T follicular helper cell	4 studies	22% ± 4%	Explore
T-helper 17 cell	4 studies	25% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	32% ± 11%	Explore
intraepithelial lymphocyte	3 studies	28% ± 5%	Explore
intermediate monocyte	3 studies	48% ± 19%	Explore
T-helper 1 cell	3 studies	41% ± 5%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	13 studies	29% ± 7%	Explore
lung	5 studies	21% ± 5%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	2041.38	577 / 578	96%	21.07	1106 / 1155
breast	92%	476.73	420 / 459	85%	11.84	953 / 1118
intestine	93%	505.20	895 / 966	83%	10.23	436 / 527
bladder	95%	517.86	20 / 21	76%	13.48	383 / 504
uterus	60%	166.60	102 / 170	91%	13.60	417 / 459
stomach	67%	224.75	239 / 359	84%	10.80	240 / 286
esophagus	70%	251.70	1006 / 1445	76%	7.24	139 / 183
thymus	64%	219.98	419 / 653	81%	14.36	492 / 605
liver	62%	231.83	141 / 226	79%	8.96	319 / 406
adrenal gland	92%	459.76	238 / 258	48%	3.83	110 / 230
skin	45%	124.05	806 / 1809	92%	21.21	432 / 472
kidney	48%	244.90	43 / 89	84%	12.95	754 / 901
prostate	63%	197.14	155 / 245	68%	4.86	342 / 502
pancreas	21%	59.72	69 / 328	94%	16.47	167 / 178
ovary	31%	87.51	56 / 180	79%	7.52	338 / 430
lymph node	0%	0	0 / 0	100%	81.09	29 / 29
spleen	100%	3760.99	241 / 241	0%	0	0 / 0
peripheral blood	99%	5819.47	923 / 929	0%	0	0 / 0
adipose	99%	882.45	1193 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	25.10	43 / 45
blood vessel	73%	381.33	973 / 1335	0%	0	0 / 0
heart	55%	173.36	475 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	50%	4.49	40 / 80
brain	2%	3.06	40 / 2642	28%	2.38	200 / 705
muscle	6%	12.77	51 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1