APPL2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009631Biological processcold acclimation
GO_1900077Biological processnegative regulation of cellular response to insulin stimulus
GO_0035729Biological processcellular response to hepatocyte growth factor stimulus
GO_0007165Biological processsignal transduction
GO_0033211Biological processadiponectin-activated signaling pathway
GO_0002024Biological processdiet induced thermogenesis
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0051289Biological processprotein homotetramerization
GO_1905303Biological processpositive regulation of macropinocytosis
GO_0045088Biological processregulation of innate immune response
GO_0046322Biological processnegative regulation of fatty acid oxidation
GO_0006606Biological processprotein import into nucleus
GO_0046325Biological processnegative regulation of glucose import
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0010762Biological processregulation of fibroblast migration
GO_2000178Biological processnegative regulation of neural precursor cell proliferation
GO_0060100Biological processpositive regulation of phagocytosis, engulfment
GO_0034143Biological processregulation of toll-like receptor 4 signaling pathway
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_1905451Biological processpositive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis
GO_0050768Biological processnegative regulation of neurogenesis
GO_0042593Biological processglucose homeostasis
GO_0023052Biological processsignaling
GO_0001726Cellular componentruffle
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0032009Cellular componentearly phagosome
GO_0016020Cellular componentmembrane
GO_0044354Cellular componentmacropinosome
GO_0031901Cellular componentearly endosome membrane
GO_0036186Cellular componentearly phagosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0031982Cellular componentvesicle
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0042802Molecular functionidentical protein binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPPL2
Protein nameAdaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
DCC-interacting protein 13-beta (Dip13-beta) (Adapter protein containing PH domain, PTB domain and leucine zipper motif 2)
SynonymsDIP13B
DescriptionFUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism . Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex . Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus . Plays a role in cell metabolism by regulating adiponecting ans insulin signaling pathways and adaptative thermogenesis (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oxidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negativeliy regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 . Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex . May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). .

AccessionsF8VS86
ENST00000553109.1
Q8NEU8
ENST00000553097.5
ENST00000551662.5 [Q8NEU8-3]
ENST00000549974.5
ENST00000546731.1
F8W124
ENST00000539978.6 [Q8NEU8-2]
H0YH86
ENST00000549056.1
F8VXB0
ENST00000547439.5
ENST00000258530.8 [Q8NEU8-1]
F8VWV2
F8VR68