PROK1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of PROK1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PROK1 at tissue level.

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0001525Biological processangiogenesis
GO_0051781Biological processpositive regulation of cell division
GO_0101023Biological processvascular endothelial cell proliferation
GO_1905564Biological processpositive regulation of vascular endothelial cell proliferation
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0001935Biological processendothelial cell proliferation
GO_0045765Biological processregulation of angiogenesis
GO_0005576Cellular componentextracellular region
GO_0008083Molecular functiongrowth factor activity

IV. Literature review

[source]
Gene namePROK1
Protein nameProkineticin-1 (Endocrine-gland-derived vascular endothelial growth factor) (EG-VEGF) (Mambakine)
SynonymsUNQ600/PRO1186
DescriptionFUNCTION: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. .

AccessionsP58294
ENST00000271331.4