IFNGR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	44 studies	39% ± 15%	Explore
endothelial cell	39 studies	32% ± 11%	Explore
fibroblast	26 studies	26% ± 10%	Explore
conventional dendritic cell	26 studies	41% ± 13%	Explore
natural killer cell	25 studies	25% ± 7%	Explore
classical monocyte	24 studies	39% ± 8%	Explore
dendritic cell	23 studies	41% ± 17%	Explore
non-classical monocyte	23 studies	41% ± 10%	Explore
monocyte	22 studies	33% ± 12%	Explore
basal cell	16 studies	33% ± 15%	Explore
microglial cell	16 studies	51% ± 19%	Explore
pericyte	16 studies	23% ± 7%	Explore
capillary endothelial cell	15 studies	40% ± 20%	Explore
B cell	14 studies	20% ± 4%	Explore
myeloid cell	14 studies	37% ± 17%	Explore
endothelial cell of artery	13 studies	41% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	26% ± 9%	Explore
plasmacytoid dendritic cell	12 studies	22% ± 6%	Explore
endothelial cell of vascular tree	12 studies	32% ± 13%	Explore
CD4-positive, alpha-beta T cell	11 studies	18% ± 3%	Explore
mucosal invariant T cell	11 studies	35% ± 12%	Explore
vein endothelial cell	11 studies	31% ± 14%	Explore
CD8-positive, alpha-beta T cell	10 studies	22% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	29% ± 9%	Explore
type I pneumocyte	9 studies	26% ± 8%	Explore
naive B cell	9 studies	23% ± 6%	Explore
T cell	8 studies	22% ± 5%	Explore
alveolar macrophage	8 studies	38% ± 8%	Explore
secretory cell	8 studies	34% ± 20%	Explore
leukocyte	8 studies	32% ± 14%	Explore
myofibroblast cell	8 studies	24% ± 9%	Explore
adipocyte	8 studies	26% ± 7%	Explore
mature NK T cell	8 studies	25% ± 10%	Explore
endothelial cell of lymphatic vessel	7 studies	23% ± 6%	Explore
neutrophil	7 studies	30% ± 6%	Explore
mononuclear phagocyte	7 studies	49% ± 18%	Explore
connective tissue cell	7 studies	25% ± 14%	Explore
epithelial cell	7 studies	37% ± 17%	Explore
ciliated cell	7 studies	38% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	7 studies	22% ± 2%	Explore
gamma-delta T cell	7 studies	26% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	22% ± 7%	Explore
mast cell	5 studies	27% ± 4%	Explore
ionocyte	5 studies	33% ± 10%	Explore
smooth muscle cell	5 studies	21% ± 3%	Explore
memory B cell	5 studies	20% ± 6%	Explore
innate lymphoid cell	5 studies	29% ± 6%	Explore
oligodendrocyte	5 studies	25% ± 7%	Explore
intermediate monocyte	4 studies	53% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	19% ± 3%	Explore
glomerular endothelial cell	3 studies	43% ± 7%	Explore
club cell	3 studies	39% ± 16%	Explore
enterocyte	3 studies	20% ± 4%	Explore
tissue-resident macrophage	3 studies	35% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	18% ± 2%	Explore
inflammatory macrophage	3 studies	34% ± 5%	Explore
muscle cell	3 studies	20% ± 2%	Explore
type II pneumocyte	3 studies	20% ± 6%	Explore
GABAergic neuron	3 studies	32% ± 5%	Explore
glutamatergic neuron	3 studies	36% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	37% ± 5%	Explore
astrocyte	3 studies	19% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	31% ± 12%	Explore
peripheral blood	14 studies	22% ± 6%	Explore
brain	8 studies	34% ± 17%	Explore
intestine	4 studies	23% ± 7%	Explore
uterus	4 studies	24% ± 8%	Explore
prostate	4 studies	21% ± 5%	Explore
kidney	3 studies	21% ± 4%	Explore
eye	3 studies	22% ± 5%	Explore
heart	3 studies	19% ± 3%	Explore
adipose	3 studies	24% ± 5%	Explore
lymph node	3 studies	25% ± 10%	Explore
breast	3 studies	23% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	16171.31	578 / 578	100%	129.73	1154 / 1155
esophagus	100%	4521.90	1443 / 1445	100%	124.27	183 / 183
stomach	100%	3990.60	358 / 359	100%	101.24	286 / 286
breast	100%	10289.53	459 / 459	100%	94.70	1114 / 1118
intestine	100%	5136.48	966 / 966	99%	102.04	524 / 527
bladder	100%	4485.05	21 / 21	99%	97.09	501 / 504
prostate	100%	5253.32	244 / 245	100%	102.41	501 / 502
thymus	100%	6017.91	652 / 653	99%	114.47	601 / 605
uterus	100%	5014.85	170 / 170	99%	107.64	454 / 459
ovary	100%	4117.54	180 / 180	99%	62.13	425 / 430
adrenal gland	100%	5125.96	258 / 258	97%	59.81	223 / 230
kidney	97%	2838.69	86 / 89	98%	88.32	887 / 901
brain	92%	3009.09	2438 / 2642	100%	117.39	703 / 705
skin	100%	5870.52	1809 / 1809	90%	50.84	423 / 472
liver	92%	4153.52	209 / 226	96%	66.73	389 / 406
pancreas	84%	2167.51	275 / 328	99%	102.79	176 / 178
adipose	100%	11261.23	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	85.17	29 / 29
spleen	100%	13850.93	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	142.77	45 / 45
heart	100%	6201.46	859 / 861	0%	0	0 / 0
blood vessel	99%	5094.61	1327 / 1335	0%	0	0 / 0
peripheral blood	99%	16753.88	923 / 929	0%	0	0 / 0
muscle	95%	3299.84	761 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	44%	16.50	35 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0009615	Biological process	response to virus
GO_0010628	Biological process	positive regulation of gene expression
GO_0019221	Biological process	cytokine-mediated signaling pathway
GO_0098586	Biological process	cellular response to virus
GO_0060333	Biological process	type II interferon-mediated signaling pathway
GO_1902004	Biological process	positive regulation of amyloid-beta formation
GO_0038196	Biological process	type III interferon-mediated signaling pathway
GO_0001774	Biological process	microglial cell activation
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_1900222	Biological process	negative regulation of amyloid-beta clearance
GO_0048143	Biological process	astrocyte activation
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0004906	Molecular function	type II interferon receptor activity
GO_0019955	Molecular function	cytokine binding
GO_0005515	Molecular function	protein binding
GO_0004896	Molecular function	cytokine receptor activity

IV. Literature review

[source]

Gene name	IFNGR1
Protein name	Interferon gamma receptor 1 isoform 1 Interferon-gamma receptor alpha chain Interferon gamma receptor 1 (IFN-gamma receptor 1) (IFN-gamma-R1) (CDw119) (Interferon gamma receptor alpha-chain) (IFN-gamma-R-alpha) (CD antigen CD119) Interferon gamma receptor 1 isoform 2 Truncated interferon-gamma receptor 1 Interferon gamma receptor 1
Synonyms
Description	FUNCTION: Receptor subunit for interferon gamma/INFG that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation . Associates with transmembrane accessory factor IFNGR2 to form a functional receptor . Upon ligand binding, the intracellular domain of IFNGR1 opens out to allow association of downstream signaling components JAK1 and JAK2. In turn, activated JAK1 phosphorylates IFNGR1 to form a docking site for STAT1. Subsequent phosphorylation of STAT1 leads to dimerization, translocation to the nucleus, and stimulation of target gene transcription . STAT3 can also be activated in a similar manner although activation seems weaker. IFNGR1 intracellular domain phosphorylation also provides a docking site for SOCS1 that regulates the JAK-STAT pathway by competing with STAT1 binding to IFNGR1 (By similarity). .
Accessions	ENST00000696695.1 ENST00000644894.1 A0A8Q3WLI2 A5HJZ4 ENST00000367739.9 [P15260-1] ENST00000645045.1 ENST00000646036.1 ENST00000414770.6 A0A8Q3SJH3 A0A2R8Y7R1 Q5TFC9 ENST00000696698.1 A0A2R8Y4U4 A0A2R8YFL3 ENST00000696697.1 A0A8Q3SJ27 ENST00000458076.6 A0A8Q3WLI6 ENST00000647124.1 ENST00000696694.1 ENST00000645753.1 P15260 ENST00000642390.1 Q7Z687 ENST00000646898.1 A0A0S2Z3R7 A0A2R8Y792 ENST00000696696.1 A0A8Q3WLG6 ENST00000696693.1 A0A0S2Z3Y2 A0A8Q3SIW7 E5QBZ2 ENST00000643119.1 ENST00000696699.1

IFNGR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review