IL15 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL15 at tissue level.

III. Associated gene sets

GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_0042102Biological processpositive regulation of T cell proliferation
GO_0050766Biological processpositive regulation of phagocytosis
GO_0007260Biological processtyrosine phosphorylation of STAT protein
GO_0035723Biological processinterleukin-15-mediated signaling pathway
GO_0045580Biological processregulation of T cell differentiation
GO_0001779Biological processnatural killer cell differentiation
GO_0048535Biological processlymph node development
GO_0030225Biological processmacrophage differentiation
GO_0032819Biological processpositive regulation of natural killer cell proliferation
GO_0007165Biological processsignal transduction
GO_1904100Biological processpositive regulation of protein O-linked glycosylation
GO_0045062Biological processextrathymic T cell selection
GO_0034105Biological processpositive regulation of tissue remodeling
GO_0007267Biological processcell-cell signaling
GO_0006955Biological processimmune response
GO_0032825Biological processpositive regulation of natural killer cell differentiation
GO_0001866Biological processNK T cell proliferation
GO_0001787Biological processnatural killer cell proliferation
GO_0050731Biological processpositive regulation of peptidyl-tyrosine phosphorylation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0050778Biological processpositive regulation of immune response
GO_0050729Biological processpositive regulation of inflammatory response
GO_0001819Biological processpositive regulation of cytokine production
GO_0050691Biological processregulation of defense response to virus by host
GO_0048469Biological processcell maturation
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0042119Biological processneutrophil activation
GO_0120163Biological processnegative regulation of cold-induced thermogenesis
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005768Cellular componentendosome
GO_0005126Molecular functioncytokine receptor binding
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameIL15
Protein nameInterleukin-15 (IL-15)
Synonyms
DescriptionFUNCTION: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems . Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines . In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection . Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits . Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 . In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity). .

AccessionsP40933
ENST00000320650.9 [P40933-1]
ENST00000477265.5 [P40933-2]
ENST00000529613.5 [P40933-1]
ENST00000394159.2 [P40933-2]
ENST00000296545.11 [P40933-1]
ENST00000514653.5 [P40933-2]