PTGES report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PTGES at tissue level.

III. Associated gene sets

GO_0019233Biological processsensory perception of pain
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0008283Biological processcell population proliferation
GO_0098869Biological processcellular oxidant detoxification
GO_0007165Biological processsignal transduction
GO_0050727Biological processregulation of inflammatory response
GO_0001516Biological processprostaglandin biosynthetic process
GO_0006693Biological processprostaglandin metabolic process
GO_0031620Biological processregulation of fever generation
GO_0032308Biological processpositive regulation of prostaglandin secretion
GO_0005641Cellular componentnuclear envelope lumen
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0004602Molecular functionglutathione peroxidase activity
GO_0043295Molecular functionglutathione binding
GO_0050220Molecular functionprostaglandin-E synthase activity
GO_0004364Molecular functionglutathione transferase activity
GO_0004667Molecular functionprostaglandin-D synthase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePTGES
Protein nameProstaglandin E synthase (EC 5.3.99.3) (Glutathione peroxidase PTGES) (EC 1.11.1.-) (Glutathione transferase PTGES) (EC 2.5.1.18) (Microsomal glutathione S-transferase 1-like 1) (MGST1-L1) (Microsomal prostaglandin E synthase 1) (MPGES-1) (p53-induced gene 12 protein)
SynonymsPGES
PIG12
MGST1L1
MPGES1
DescriptionFUNCTION: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli . Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 . In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively . .

AccessionsO14684
ENST00000340607.5