TMED1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0007030Biological processGolgi organization
GO_0006886Biological processintracellular protein transport
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0007267Biological processcell-cell signaling
GO_0045087Biological processinnate immune response
GO_0033116Cellular componentendoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005793Cellular componentendoplasmic reticulum-Golgi intermediate compartment
GO_0005794Cellular componentGolgi apparatus
GO_0005886Cellular componentplasma membrane
GO_0030134Cellular componentCOPII-coated ER to Golgi transport vesicle
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0038024Molecular functioncargo receptor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTMED1
Protein nameTransmembrane emp24 domain-containing protein 1 (Interleukin-1 receptor-like 1 ligand) (Putative T1/ST2 receptor-binding protein) (p24 family protein gamma-1) (Tp24) (p24gamma1)
Transmembrane p24 trafficking protein 1
Transmembrane emp24 domain-containing protein 1 (p24 family protein gamma-1)
SynonymsIL1RL1L
IL1RL1LG
DescriptionFUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 . Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 . .

AccessionsENST00000214869.7
ENST00000591695.5
ENST00000589638.1
K7ES06
K7EQ63
ENST00000588259.5
Q13445
ENST00000591157.1
ENST00000588289.1
K7EIR1
K7ERK5
K7EIN4
K7ER03
ENST00000586835.1