CBLB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0050860Biological processnegative regulation of T cell receptor signaling pathway
GO_0035739Biological processCD4-positive, alpha-beta T cell proliferation
GO_0007165Biological processsignal transduction
GO_0050852Biological processT cell receptor signaling pathway
GO_2000583Biological processregulation of platelet-derived growth factor receptor-alpha signaling pathway
GO_0006955Biological processimmune response
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0035556Biological processintracellular signal transduction
GO_0002870Biological processT cell anergy
GO_0030163Biological processprotein catabolic process
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0002669Biological processpositive regulation of T cell anergy
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_2000562Biological processnegative regulation of CD4-positive, alpha-beta T cell proliferation
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameCBLB
Protein nameE3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Cbl proto-oncogene B
SynonymsNbla00127
RNF56
DescriptionFUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T-cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. In association with CBL, required for proper feedback inhibition of ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway via ubiquitination and internalization of PDGFRA (By similarity). .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

AccessionsENST00000643192.1
A0A2R8Y8D8
ENST00000645759.1
Q13191
ENST00000646499.1
ENST00000405772.5 [Q13191-2]
ENST00000443752.2
C9JU85
C9JRB3
ENST00000394030.8 [Q13191-1]
ENST00000643322.1
A0A2R8Y582
C9K048
A0A2R8Y7I2
ENST00000447441.6
ENST00000438603.6
A0A2R8Y875
ENST00000646825.1
ENST00000642241.1
A0A2R8Y5E1
A0A2R8YFD4
ENST00000643403.1
ENST00000403724.5 [Q13191-3]
A0A2R8YDW4
ENST00000645425.1