I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| pericyte | 7 studies | 21% ± 4% | |
| extravillous trophoblast | 3 studies | 19% ± 2% | |
| endothelial cell | 3 studies | 19% ± 2% | |
| fibroblast | 3 studies | 21% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| pericyte | 7 studies | 21% ± 4% | |
| extravillous trophoblast | 3 studies | 19% ± 2% | |
| endothelial cell | 3 studies | 19% ± 2% | |
| fibroblast | 3 studies | 21% ± 3% |
Insufficient scRNA-seq data for expression of SYDE1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| kidney | 100% | 2315.66 | 89 / 89 | 92% | 28.51 | 826 / 901 |
| skin | 91% | 2541.21 | 1653 / 1809 | 100% | 61.02 | 471 / 472 |
| ovary | 100% | 3440.94 | 180 / 180 | 91% | 18.09 | 392 / 430 |
| breast | 100% | 2748.35 | 459 / 459 | 89% | 12.70 | 999 / 1118 |
| lung | 99% | 2764.02 | 575 / 578 | 85% | 11.47 | 986 / 1155 |
| prostate | 100% | 2957.73 | 244 / 245 | 84% | 10.62 | 420 / 502 |
| thymus | 100% | 2037.35 | 651 / 653 | 81% | 9.09 | 490 / 605 |
| bladder | 100% | 3664.14 | 21 / 21 | 80% | 12.23 | 403 / 504 |
| esophagus | 92% | 3136.62 | 1334 / 1445 | 87% | 13.82 | 159 / 183 |
| uterus | 100% | 4811.02 | 170 / 170 | 79% | 20.69 | 361 / 459 |
| intestine | 97% | 3060.92 | 941 / 966 | 79% | 10.68 | 415 / 527 |
| adrenal gland | 100% | 1895.83 | 258 / 258 | 68% | 9.92 | 157 / 230 |
| stomach | 79% | 1733.50 | 284 / 359 | 85% | 14.18 | 244 / 286 |
| brain | 41% | 308.41 | 1078 / 2642 | 98% | 23.86 | 693 / 705 |
| pancreas | 42% | 329.27 | 139 / 328 | 95% | 20.22 | 169 / 178 |
| adipose | 100% | 3353.56 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 5394.36 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 63.88 | 80 / 80 |
| ureter | 0% | 0 | 0 / 0 | 100% | 7.38 | 1 / 1 |
| heart | 100% | 1845.25 | 858 / 861 | 0% | 0 | 0 / 0 |
| spleen | 99% | 2019.85 | 239 / 241 | 0% | 0 | 0 / 0 |
| liver | 23% | 182.80 | 51 / 226 | 45% | 5.85 | 182 / 406 |
| tonsil | 0% | 0 | 0 / 0 | 64% | 8.04 | 29 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 4.00 | 14 / 29 |
| muscle | 31% | 236.26 | 249 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007165 | Biological process | signal transduction |
| GO_0030036 | Biological process | actin cytoskeleton organization |
| GO_1901165 | Biological process | positive regulation of trophoblast cell migration |
| GO_0016477 | Biological process | cell migration |
| GO_0090630 | Biological process | activation of GTPase activity |
| GO_0051493 | Biological process | regulation of cytoskeleton organization |
| GO_0046578 | Biological process | regulation of Ras protein signal transduction |
| GO_0097060 | Cellular component | synaptic membrane |
| GO_0030695 | Molecular function | GTPase regulator activity |
| GO_0005096 | Molecular function | GTPase activator activity |
| Gene name | SYDE1 |
| Protein name | Synapse defective 1, Rho GTPase, homolog 1 (C. elegans), isoform CRA_a (Synapse defective Rho GTPase homolog 1) Rho GTPase-activating protein SYDE1 (Synapse defective protein 1 homolog 1) (Protein syd-1 homolog 1) SYDE1 Synapse defective Rho GTPase homolog 1 |
| Synonyms | hCG_38601 |
| Description | FUNCTION: GTPase activator for the Rho-type GTPases. As a GCM1 downstream effector, it is involved in placental development and positively regulates trophoblast cells migration. It regulates cytoskeletal remodeling by controlling the activity of Rho GTPases including RHOA, CDC42 and RAC1 . . |
| Accessions | ENST00000600252.5 M0R3D3 ENST00000342784.7 [Q6ZW31-1] A0A2X0SFL9 M0QXZ8 ENST00000597977.5 Q6ZW31 ENST00000602203.1 ENST00000600440.5 [Q6ZW31-2] M0R101 |
