HBS1L report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006412Biological processtranslation
GO_0070966Biological processnuclear-transcribed mRNA catabolic process, no-go decay
GO_0072344Biological processrescue of stalled ribosome
GO_0032790Biological processribosome disassembly
GO_0006417Biological processregulation of translation
GO_0022626Cellular componentcytosolic ribosome
GO_0070062Cellular componentextracellular exosome
GO_0005829Cellular componentcytosol
GO_1990533Cellular componentDom34-Hbs1 complex
GO_0016020Cellular componentmembrane
GO_0005525Molecular functionGTP binding
GO_0003746Molecular functiontranslation elongation factor activity
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameHBS1L
Protein nameHBS1 like translational GTPase (HBS1-like (S. cerevisiae), isoform CRA_e)
HBS1 like translational GTPase (cDNA FLJ52343, highly similar to HBS1-like protein)
HBS1-like (S. cerevisiae), isoform CRA_a
HBS1-like protein
HBS1-like protein (EC 3.6.5.-) (ERFS)
HBS1 like translational GTPase
SynonymshCG_2039561
DKFZp434G247
HBS1
KIAA1038
DescriptionFUNCTION: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway . The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel . Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway . .

AccessionsD9YZV0
Q9NSX9
ENST00000415177.6
E9PHZ9
E9PJ90
ENST00000367837.10 [Q9Y450-1]
H0YES5
ENST00000367820.6
ENST00000367822.9 [Q9Y450-2]
J3QT46
ENST00000529169.1
E9PMN1
G5E991
ENST00000527507.1
ENST00000314674.7
H0YDX7
E9PN23
ENST00000529641.5
E9PS53
ENST00000533274.5
B7Z524
ENST00000367826.6 [Q9Y450-4]
E9PLR4
ENST00000524715.5
ENST00000529882.5
H0YD85
ENST00000527578.5
Q9Y450
ENST00000526100.5
ENST00000525067.1