Name | Number of supported studies | Average coverage | |
---|---|---|---|
oligodendrocyte | 14 studies | 39% ± 17% | |
endothelial cell | 7 studies | 27% ± 9% | |
regulatory T cell | 6 studies | 19% ± 2% | |
GABAergic neuron | 6 studies | 41% ± 20% | |
astrocyte | 6 studies | 32% ± 14% | |
glutamatergic neuron | 5 studies | 52% ± 26% | |
interneuron | 5 studies | 39% ± 24% | |
microglial cell | 5 studies | 22% ± 5% | |
oligodendrocyte precursor cell | 5 studies | 28% ± 11% | |
CD8-positive, alpha-beta T cell | 5 studies | 18% ± 2% | |
plasmablast | 4 studies | 41% ± 17% | |
CD4-positive, alpha-beta T cell | 4 studies | 21% ± 1% | |
neuron | 4 studies | 32% ± 14% | |
erythroblast | 4 studies | 30% ± 12% | |
epithelial cell | 4 studies | 36% ± 7% | |
ciliated cell | 4 studies | 23% ± 5% | |
fibroblast | 4 studies | 19% ± 1% | |
natural killer cell | 4 studies | 18% ± 2% | |
endothelial cell of lymphatic vessel | 4 studies | 17% ± 2% | |
macrophage | 4 studies | 20% ± 4% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 3 studies | 20% ± 2% | |
naive thymus-derived CD8-positive, alpha-beta T cell | 3 studies | 19% ± 4% | |
B cell | 3 studies | 18% ± 1% | |
mast cell | 3 studies | 25% ± 7% | |
erythrocyte | 3 studies | 33% ± 13% | |
basal cell | 3 studies | 31% ± 5% | |
plasmacytoid dendritic cell | 3 studies | 19% ± 4% | |
T cell | 3 studies | 18% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 2127.36 | 459 / 459 | 100% | 21.92 | 1118 / 1118 |
esophagus | 100% | 2108.03 | 1445 / 1445 | 100% | 17.83 | 183 / 183 |
uterus | 100% | 2085.94 | 170 / 170 | 100% | 15.45 | 459 / 459 |
brain | 100% | 3058.68 | 2641 / 2642 | 100% | 14.85 | 705 / 705 |
ovary | 100% | 1956.19 | 180 / 180 | 100% | 10.73 | 429 / 430 |
thymus | 100% | 1758.24 | 653 / 653 | 100% | 13.61 | 602 / 605 |
prostate | 100% | 1706.75 | 244 / 245 | 100% | 12.10 | 501 / 502 |
lung | 99% | 1749.06 | 574 / 578 | 100% | 14.79 | 1155 / 1155 |
pancreas | 100% | 1446.49 | 327 / 328 | 99% | 9.38 | 177 / 178 |
intestine | 100% | 2017.96 | 966 / 966 | 99% | 12.92 | 522 / 527 |
bladder | 100% | 2024.14 | 21 / 21 | 99% | 12.65 | 499 / 504 |
stomach | 100% | 1657.19 | 359 / 359 | 99% | 12.60 | 283 / 286 |
liver | 100% | 1720.75 | 225 / 226 | 98% | 9.10 | 399 / 406 |
adrenal gland | 100% | 2334.52 | 258 / 258 | 97% | 11.76 | 223 / 230 |
kidney | 100% | 1422.47 | 89 / 89 | 96% | 9.51 | 864 / 901 |
skin | 100% | 2658.80 | 1807 / 1809 | 95% | 14.16 | 449 / 472 |
adipose | 100% | 2124.85 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 11.92 | 29 / 29 |
muscle | 100% | 5419.70 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1488.26 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 17.18 | 45 / 45 |
blood vessel | 100% | 2217.23 | 1334 / 1335 | 0% | 0 | 0 / 0 |
heart | 95% | 1914.71 | 814 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 79% | 6.54 | 63 / 80 |
peripheral blood | 73% | 1559.99 | 681 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0007165 | Biological process | signal transduction |
GO_0006412 | Biological process | translation |
GO_0070966 | Biological process | nuclear-transcribed mRNA catabolic process, no-go decay |
GO_0072344 | Biological process | rescue of stalled ribosome |
GO_0032790 | Biological process | ribosome disassembly |
GO_0006417 | Biological process | regulation of translation |
GO_0022626 | Cellular component | cytosolic ribosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0005829 | Cellular component | cytosol |
GO_1990533 | Cellular component | Dom34-Hbs1 complex |
GO_0016020 | Cellular component | membrane |
GO_0005525 | Molecular function | GTP binding |
GO_0003746 | Molecular function | translation elongation factor activity |
GO_0005515 | Molecular function | protein binding |
GO_0003924 | Molecular function | GTPase activity |
Gene name | HBS1L |
Protein name | HBS1 like translational GTPase (HBS1-like (S. cerevisiae), isoform CRA_e) HBS1 like translational GTPase (cDNA FLJ52343, highly similar to HBS1-like protein) HBS1-like (S. cerevisiae), isoform CRA_a HBS1-like protein HBS1-like protein (EC 3.6.5.-) (ERFS) HBS1 like translational GTPase |
Synonyms | hCG_2039561 DKFZp434G247 HBS1 KIAA1038 |
Description | FUNCTION: GTPase component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway . The Pelota-HBS1L complex recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel . Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway . . |
Accessions | D9YZV0 Q9NSX9 ENST00000415177.6 E9PHZ9 E9PJ90 ENST00000367837.10 [Q9Y450-1] H0YES5 ENST00000367820.6 ENST00000367822.9 [Q9Y450-2] J3QT46 ENST00000529169.1 E9PMN1 G5E991 ENST00000527507.1 ENST00000314674.7 H0YDX7 E9PN23 ENST00000529641.5 E9PS53 ENST00000533274.5 B7Z524 ENST00000367826.6 [Q9Y450-4] E9PLR4 ENST00000524715.5 ENST00000529882.5 H0YD85 ENST00000527578.5 Q9Y450 ENST00000526100.5 ENST00000525067.1 |