CNGA3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CNGA3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CNGA3 at tissue level.

III. Associated gene sets

GO_0007601Biological processvisual perception
GO_0098659Biological processinorganic cation import across plasma membrane
GO_0032026Biological processresponse to magnesium ion
GO_0007165Biological processsignal transduction
GO_0051591Biological processresponse to cAMP
GO_0098655Biological processmonoatomic cation transmembrane transport
GO_0006812Biological processmonoatomic cation transport
GO_0035725Biological processsodium ion transmembrane transport
GO_0070588Biological processcalcium ion transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0043204Cellular componentperikaryon
GO_1902495Cellular componenttransmembrane transporter complex
GO_0043194Cellular componentaxon initial segment
GO_0030425Cellular componentdendrite
GO_0017071Cellular componentintracellular cyclic nucleotide activated cation channel complex
GO_0097386Cellular componentglial cell projection
GO_0005272Molecular functionsodium channel activity
GO_0030553Molecular functioncGMP binding
GO_0044877Molecular functionprotein-containing complex binding
GO_0045296Molecular functioncadherin binding
GO_0017022Molecular functionmyosin binding
GO_0015276Molecular functionligand-gated monoatomic ion channel activity
GO_0005223Molecular functionintracellularly cGMP-activated cation channel activity
GO_0005222Molecular functionintracellularly cAMP-activated cation channel activity
GO_0005515Molecular functionprotein binding
GO_0005262Molecular functioncalcium channel activity

IV. Literature review

[source]
Gene nameCNGA3
Protein nameAlternative protein CNGA3
Cyclic nucleotide-gated cation channel alpha-3 (Cone photoreceptor cGMP-gated channel subunit alpha) (Cyclic nucleotide-gated channel alpha-3) (CNG channel alpha-3) (CNG-3) (CNG3)
Cyclic nucleotide-gated cation channel alpha-3
SynonymsCNCG3
DescriptionFUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones. .

AccessionsA0A097I4X7
L8E7M2
ENST00000436404.6 [Q16281-2]
ENST00000272602.7 [Q16281-1]
Q16281