TYROBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030316Biological processosteoclast differentiation
GO_0030900Biological processforebrain development
GO_0007165Biological processsignal transduction
GO_0048678Biological processresponse to axon injury
GO_0010628Biological processpositive regulation of gene expression
GO_0032911Biological processnegative regulation of transforming growth factor beta1 production
GO_0006968Biological processcellular defense response
GO_0002222Biological processstimulatory killer cell immunoglobulin-like receptor signaling pathway
GO_2000010Biological processpositive regulation of protein localization to cell surface
GO_0032693Biological processnegative regulation of interleukin-10 production
GO_0034241Biological processpositive regulation of macrophage fusion
GO_0002223Biological processstimulatory C-type lectin receptor signaling pathway
GO_0032480Biological processnegative regulation of type I interferon production
GO_1902685Biological processpositive regulation of receptor localization to synapse
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0030036Biological processactin cytoskeleton organization
GO_0043277Biological processapoptotic cell clearance
GO_0035556Biological processintracellular signal transduction
GO_0050821Biological processprotein stabilization
GO_0032816Biological processpositive regulation of natural killer cell activation
GO_1900272Biological processnegative regulation of long-term synaptic potentiation
GO_0032930Biological processpositive regulation of superoxide anion generation
GO_0002274Biological processmyeloid leukocyte activation
GO_1904151Biological processpositive regulation of microglial cell mediated cytotoxicity
GO_2001206Biological processpositive regulation of osteoclast development
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0030889Biological processnegative regulation of B cell proliferation
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0002282Biological processmicroglial cell activation involved in immune response
GO_0002283Biological processneutrophil activation involved in immune response
GO_0030667Cellular componentsecretory granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0009986Cellular componentcell surface
GO_0042803Molecular functionprotein homodimerization activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005102Molecular functionsignaling receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTYROBP
Protein nameTYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12) (Killer-activating receptor-associated protein) (KAR-associated protein)
TYRO protein tyrosine kinase-binding protein (DNAX-activation protein 12)
Transmembrane immune signaling adaptor TYROBP
SynonymsDAP12
KARAP
DescriptionFUNCTION: Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors . TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation . Also has an inhibitory role in some cells . Non-covalently associates with activating receptors of the CD300 family to mediate cell activation . Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor . Associates with natural killer (NK) cell receptors such as KIR2DS2 and the KLRD1/KLRC2 heterodimer to mediate NK cell activation . Also enhances trafficking and cell surface expression of NK cell receptors KIR2DS1, KIR2DS2 and KIR2DS4 and ensures their stability at the cell surface . Associates with SIRPB1 to mediate activation of myeloid cells such as monocytes and dendritic cells . Associates with TREM1 to mediate activation of neutrophils and monocytes . Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival . Association with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages . Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines . In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). Positively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allostimulatory ability (By similarity). Negatively regulates B cell proliferation . Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity). .

AccessionsK7ES93
ENST00000544690.6 [O43914-3]
ENST00000589517.1 [O43914-2]
X6RGC9
O43914
K7EKK0
ENST00000424586.7
ENST00000586946.1
ENST00000262629.9 [O43914-1]
ENST00000585901.6
ENST00000587837.5