SLA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	33 studies	31% ± 13%	Explore
natural killer cell	33 studies	33% ± 11%	Explore
T cell	25 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	25 studies	28% ± 10%	Explore
CD4-positive, alpha-beta T cell	23 studies	25% ± 7%	Explore
regulatory T cell	22 studies	32% ± 10%	Explore
classical monocyte	21 studies	33% ± 11%	Explore
monocyte	17 studies	30% ± 12%	Explore
non-classical monocyte	17 studies	31% ± 10%	Explore
mature NK T cell	15 studies	32% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	31% ± 8%	Explore
gamma-delta T cell	12 studies	26% ± 6%	Explore
myeloid cell	12 studies	31% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	27% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	27% ± 6%	Explore
microglial cell	11 studies	32% ± 14%	Explore
mucosal invariant T cell	10 studies	28% ± 8%	Explore
dendritic cell	9 studies	26% ± 5%	Explore
alveolar macrophage	8 studies	28% ± 11%	Explore
neutrophil	8 studies	32% ± 11%	Explore
mast cell	7 studies	22% ± 6%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	25% ± 3%	Explore
leukocyte	7 studies	26% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	25% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	33% ± 10%	Explore
T follicular helper cell	7 studies	32% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	24% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	25% ± 7%	Explore
mononuclear phagocyte	5 studies	35% ± 12%	Explore
conventional dendritic cell	5 studies	30% ± 10%	Explore
exhausted T cell	4 studies	28% ± 10%	Explore
lymphocyte	4 studies	42% ± 12%	Explore
intermediate monocyte	4 studies	53% ± 15%	Explore
CD4-positive helper T cell	4 studies	26% ± 9%	Explore
innate lymphoid cell	4 studies	35% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	29% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	49% ± 10%	Explore
T-helper 17 cell	3 studies	34% ± 1%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	24% ± 7%	Explore
lung	6 studies	25% ± 7%	Explore
brain	4 studies	21% ± 4%	Explore
lymph node	3 studies	25% ± 5%	Explore
liver	3 studies	29% ± 10%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	98%	4942.38	643 / 653	95%	21.53	575 / 605
lung	100%	4687.10	578 / 578	88%	12.20	1017 / 1155
kidney	87%	1002.66	77 / 89	84%	13.52	756 / 901
breast	81%	1141.67	373 / 459	88%	10.27	980 / 1118
bladder	90%	1255.81	19 / 21	59%	5.85	295 / 504
stomach	75%	811.69	269 / 359	70%	7.38	201 / 286
intestine	79%	1446.72	762 / 966	64%	6.00	336 / 527
uterus	64%	546.81	108 / 170	69%	6.38	317 / 459
brain	38%	373.88	1001 / 2642	92%	16.54	651 / 705
prostate	72%	920.22	176 / 245	55%	3.64	275 / 502
adrenal gland	93%	1395.07	241 / 258	33%	2.52	76 / 230
esophagus	56%	565.83	804 / 1445	63%	4.91	116 / 183
skin	39%	320.00	697 / 1809	71%	10.11	333 / 472
pancreas	24%	199.90	80 / 328	84%	14.33	150 / 178
lymph node	0%	0	0 / 0	100%	64.88	29 / 29
spleen	100%	11833.77	241 / 241	0%	0	0 / 0
adipose	93%	2223.10	1120 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	84%	11.75	38 / 45
peripheral blood	81%	22202.57	757 / 929	0%	0	0 / 0
ovary	31%	267.48	56 / 180	50%	3.26	215 / 430
liver	42%	417.69	96 / 226	38%	3.00	153 / 406
blood vessel	66%	998.38	880 / 1335	0%	0	0 / 0
heart	40%	410.02	348 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	16%	1.06	13 / 80
muscle	5%	32.33	41 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0043408	Biological process	regulation of MAPK cascade
GO_0008180	Cellular component	COP9 signalosome
GO_0005768	Cellular component	endosome
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005886	Cellular component	plasma membrane
GO_0005737	Cellular component	cytoplasm
GO_0005154	Molecular function	epidermal growth factor receptor binding
GO_0005515	Molecular function	protein binding
GO_0001784	Molecular function	phosphotyrosine residue binding

IV. Literature review

[source]

Gene name	SLA
Protein name	Src like adaptor Src-like-adapter (Src-like-adapter protein 1) (SLAP-1) (hSLAP)
Synonyms	SLAP1 SLAP
Description	FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. .
Accessions	E5RK29 ENST00000522432.5 ENST00000519747.5 E5RJ69 Q13239 E5RH80 E5RHT2 ENST00000521302.5 ENST00000395352.7 [Q13239-3] ENST00000523610.5 ENST00000519558.5 ENST00000522119.5 ENST00000338087.10 [Q13239-1] E5RGG0 ENST00000519341.5 ENST00000517648.5 [Q13239-4] ENST00000427060.6 [Q13239-5] ENST00000524345.5 [Q13239-2] E5RJB0 E5RK95

SLA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review