VGF report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0001541Biological processovarian follicle development
GO_0007165Biological processsignal transduction
GO_0032868Biological processresponse to insulin
GO_0002021Biological processresponse to dietary excess
GO_0099538Biological processsynaptic signaling via neuropeptide
GO_0051591Biological processresponse to cAMP
GO_0048167Biological processregulation of synaptic plasticity
GO_0048168Biological processregulation of neuronal synaptic plasticity
GO_0009409Biological processresponse to cold
GO_0019953Biological processsexual reproduction
GO_0042742Biological processdefense response to bacterium
GO_0033500Biological processcarbohydrate homeostasis
GO_0030073Biological processinsulin secretion
GO_0042593Biological processglucose homeostasis
GO_0098978Cellular componentglutamatergic synapse
GO_0005615Cellular componentextracellular space
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0043025Cellular componentneuronal cell body
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0030133Cellular componenttransport vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005179Molecular functionhormone activity
GO_0008083Molecular functiongrowth factor activity
GO_0003674Molecular functionmolecular_function
GO_0005184Molecular functionneuropeptide hormone activity

IV. Literature review

[source]
Gene nameVGF
Protein nameVGF protein
Neurosecretory protein VGF [Cleaved into: Neuroendocrine regulatory peptide-1 (NERP-1); Neuroendocrine regulatory peptide-2 (NERP-2); VGF-derived peptide TLQP-21; VGF-derived peptide TLQP-62; Antimicrobial peptide VGF[554-577]]
Synonyms
DescriptionFUNCTION: [Neurosecretory protein VGF]: Secreted polyprotein that is packaged and proteolytically processed by prohormone convertases PCSK1 and PCSK2 in a cell-type-specific manner (By similarity). VGF and peptides derived from its processing play many roles in neurogenesis and neuroplasticity associated with learning, memory, depression and chronic pain (By similarity). .; FUNCTION: [Neuroendocrine regulatory peptide-1]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Suppresses presynaptic glutamatergic neurons connected to vasopressin neurons. .; FUNCTION: [Neuroendocrine regulatory peptide-2]: Plays a role in the control of body fluid homeostasis by regulating vasopressin release. Activates GABAergic interneurons which are inhibitory neurons of the nervous system and thereby suppresses presynaptic glutamatergic neurons (By similarity). Stimulates also feeding behavior in an orexin-dependent manner in the hypothalamus (By similarity). Functions as a positive regulator for the activation of orexin neurons resulting in elevated gastric acid secretion and gastric emptying (By similarity). .; FUNCTION: [VGF-derived peptide TLQP-21]: Secreted multifunctional neuropeptide that binds to different cell receptors and thereby plays multiple physiological roles including modulation of energy expenditure, pain, response to stress, gastric regulation, glucose homeostasis as well as lipolysis (By similarity). Activates the G-protein-coupled receptor C3AR1 via a folding-upon-binding mechanism leading to enhanced lipolysis in adipocytes (By similarity). Interacts with C1QBP receptor in macrophages and microglia causing increased levels of intracellular calcium and hypersensitivity (By similarity). .; FUNCTION: [VGF-derived peptide TLQP-62]: Plays a role in the regulation of memory formation and depression-related behaviors potentially by influencing synaptic plasticity and neurogenesis. Induces acute and transient activation of the NTRK2/TRKB receptor and subsequent CREB phosphorylation (By similarity). Induces also insulin secretion in insulinoma cells by increasing intracellular calcium mobilization (By similarity). .; FUNCTION: [Antimicrobial peptide VGF[554-577]]: Has bactericidal activity against M. luteus, and antifungal activity against P. Pastoris. .

AccessionsENST00000445482.2
O15240
ENST00000249330.3
Q05BJ3