CBLC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CBLC at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0007165Biological processsignal transduction
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0007166Biological processcell surface receptor signaling pathway
GO_0050821Biological processprotein stabilization
GO_1990790Biological processresponse to glial cell derived neurotrophic factor
GO_0043407Biological processnegative regulation of MAP kinase activity
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0008270Molecular functionzinc ion binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding
GO_0001784Molecular functionphosphotyrosine residue binding
GO_0030971Molecular functionreceptor tyrosine kinase binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameCBLC
Protein nameE3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
E3 ubiquitin-protein ligase CBL-C (EC 2.3.2.27) (RING finger protein 57) (RING-type E3 ubiquitin transferase CBL-C) (SH3-binding protein CBL-3) (SH3-binding protein CBL-C) (Signal transduction protein CBL-C)
SynonymsRNF57
CBL3
DescriptionFUNCTION: Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival. .

FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. .

AccessionsENST00000341505.4 [Q9ULV8-2]
Q9ULV8
A0A2R8Y647
ENST00000647063.1
ENST00000647358.2 [Q9ULV8-1]