PDCL report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PDCL at tissue level.

III. Associated gene sets

GO_0045880Biological processpositive regulation of smoothened signaling pathway
GO_0007165Biological processsignal transduction
GO_0007601Biological processvisual perception
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0030030Biological processcell projection organization
GO_1902605Biological processheterotrimeric G-protein complex assembly
GO_0005929Cellular componentcilium
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDCL
Protein namePhosducin like
Phosducin-like protein (PHLP)
SynonymsPHLOP1
PhLP1
DescriptionFUNCTION: Acts as a positive regulator of hedgehog signaling and regulates ciliary function. .; FUNCTION: [Isoform 1]: Functions as a co-chaperone for CCT in the assembly of heterotrimeric G protein complexes, facilitates the assembly of both Gbeta-Ggamma and RGS-Gbeta5 heterodimers.; FUNCTION: [Isoform 2]: Acts as a negative regulator of heterotrimeric G proteins assembly by trapping the preloaded G beta subunits inside the CCT chaperonin.

AccessionsENST00000436632.5
H0Y3M0
Q13371
ENST00000394285.3
ENST00000259467.9 [Q13371-1]
H0Y5D3