TYRO3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007218Biological processneuropeptide signaling pathway
GO_0007283Biological processspermatogenesis
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0001779Biological processnatural killer cell differentiation
GO_0070527Biological processplatelet aggregation
GO_0051250Biological processnegative regulation of lymphocyte activation
GO_0007165Biological processsignal transduction
GO_0007275Biological processmulticellular organism development
GO_1903902Biological processpositive regulation of viral life cycle
GO_0001764Biological processneuron migration
GO_0007155Biological processcell adhesion
GO_0042698Biological processovulation cycle
GO_0051649Biological processestablishment of localization in cell
GO_0030168Biological processplatelet activation
GO_0032940Biological processsecretion by cell
GO_0045824Biological processnegative regulation of innate immune response
GO_0033674Biological processpositive regulation of kinase activity
GO_0046718Biological processsymbiont entry into host cell
GO_0051402Biological processneuron apoptotic process
GO_0043277Biological processapoptotic cell clearance
GO_0050728Biological processnegative regulation of inflammatory response
GO_0060068Biological processvagina development
GO_0034446Biological processsubstrate adhesion-dependent cell spreading
GO_0070050Biological processneuron cellular homeostasis
GO_0006909Biological processphagocytosis
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0043491Biological processphosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0021885Biological processforebrain cell migration
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0007399Biological processnervous system development
GO_0046777Biological processprotein autophosphorylation
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0016477Biological processcell migration
GO_0043235Cellular componentreceptor complex
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005635Cellular componentnuclear envelope
GO_0009986Cellular componentcell surface
GO_0005634Cellular componentnucleus
GO_0043548Molecular functionphosphatidylinositol 3-kinase binding
GO_0004713Molecular functionprotein tyrosine kinase activity
GO_0001618Molecular functionvirus receptor activity
GO_0004714Molecular functiontransmembrane receptor protein tyrosine kinase activity
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTYRO3
Protein nameTyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1)
TYRO3 protein tyrosine kinase
Tyrosine-protein kinase receptor TYRO3
Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)
SynonymsDTK
RSE
BYK
SKY
TIF
DescriptionFUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. .; FUNCTION: (Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. .; FUNCTION: (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. .

AccessionsH0YN24
H3BPR7
ENST00000559815.1
H0YKZ2
ENST00000559066.5
Q06418
ENST00000568343.1
H0YNK6
ENST00000263798.8
Q8N6J3
ENST00000559851.1