PI4KB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007040Biological processlysosome organization
GO_0006898Biological processreceptor-mediated endocytosis
GO_0007165Biological processsignal transduction
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0048839Biological processinner ear development
GO_0048015Biological processphosphatidylinositol-mediated signaling
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005768Cellular componentendosome
GO_0030867Cellular componentrough endoplasmic reticulum membrane
GO_0071889Molecular function14-3-3 protein binding
GO_0005524Molecular functionATP binding
GO_0004430Molecular function1-phosphatidylinositol 4-kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePI4KB
Protein namePhosphatidylinositol 4-kinase beta (EC 2.7.1.67)
Phosphatidylinositol 4-kinase beta
Phosphatidylinositol 4-kinase beta (PI4K-beta) (PI4Kbeta) (PtdIns 4-kinase beta) (EC 2.7.1.67) (NPIK) (PI4K92) (PI4KIII)
SynonymsPIK4CB
DescriptionFUNCTION: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) . May play an important role in the inner ear development. .; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication . Recruited by ACBD3 at the viral replication sites . .; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. .

AccessionsENST00000489223.2
A0A0A0MSL0
Q9UBF8
ENST00000455060.5
ENST00000446339.1
ENST00000438243.2
H0Y4F8
ENST00000368873.6 [Q9UBF8-1]
H0YCW3
E9PL47
ENST00000430800.5
ENST00000368872.5 [Q9UBF8-2]
A6PVV8
ENST00000368874.8 [Q9UBF8-2]
A0A0B4J1S8
ENST00000368875.6
ENST00000529142.5 [Q9UBF8-3]
ENST00000489889.2
F8W860