Name | Number of supported studies | Average coverage | |
---|---|---|---|
classical monocyte | 11 studies | 27% ± 11% | |
macrophage | 10 studies | 24% ± 9% | |
glutamatergic neuron | 8 studies | 39% ± 25% | |
microglial cell | 8 studies | 26% ± 9% | |
GABAergic neuron | 8 studies | 38% ± 22% | |
non-classical monocyte | 7 studies | 25% ± 11% | |
endothelial cell | 7 studies | 28% ± 10% | |
oligodendrocyte | 7 studies | 28% ± 8% | |
monocyte | 7 studies | 24% ± 6% | |
interneuron | 6 studies | 37% ± 23% | |
myeloid cell | 6 studies | 24% ± 12% | |
epithelial cell | 5 studies | 33% ± 11% | |
astrocyte | 5 studies | 30% ± 8% | |
oligodendrocyte precursor cell | 5 studies | 30% ± 7% | |
neuron | 4 studies | 33% ± 7% | |
mononuclear phagocyte | 4 studies | 19% ± 4% | |
GABAergic interneuron | 3 studies | 22% ± 2% | |
retinal cone cell | 3 studies | 29% ± 6% | |
fibroblast | 3 studies | 24% ± 6% | |
type II pneumocyte | 3 studies | 22% ± 5% | |
dendritic cell | 3 studies | 30% ± 11% | |
basal cell | 3 studies | 30% ± 16% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 9 studies | 36% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 5494.80 | 2642 / 2642 | 100% | 19.30 | 704 / 705 |
breast | 100% | 2828.43 | 459 / 459 | 100% | 17.97 | 1113 / 1118 |
esophagus | 100% | 3896.27 | 1445 / 1445 | 99% | 12.70 | 182 / 183 |
lung | 100% | 3578.89 | 578 / 578 | 99% | 12.66 | 1148 / 1155 |
skin | 100% | 3076.96 | 1808 / 1809 | 99% | 15.00 | 466 / 472 |
intestine | 100% | 4226.88 | 966 / 966 | 98% | 8.24 | 519 / 527 |
prostate | 100% | 3682.30 | 245 / 245 | 98% | 10.49 | 494 / 502 |
kidney | 100% | 3656.48 | 89 / 89 | 98% | 12.06 | 886 / 901 |
stomach | 100% | 2557.64 | 359 / 359 | 98% | 9.18 | 281 / 286 |
thymus | 100% | 2930.64 | 653 / 653 | 98% | 11.12 | 594 / 605 |
bladder | 100% | 4717.57 | 21 / 21 | 98% | 9.65 | 492 / 504 |
ovary | 100% | 3210.21 | 180 / 180 | 97% | 7.90 | 419 / 430 |
uterus | 100% | 3694.42 | 170 / 170 | 97% | 9.20 | 444 / 459 |
pancreas | 98% | 1469.89 | 320 / 328 | 99% | 10.41 | 176 / 178 |
adrenal gland | 100% | 2923.18 | 258 / 258 | 93% | 8.10 | 214 / 230 |
liver | 99% | 1527.62 | 224 / 226 | 91% | 8.50 | 370 / 406 |
adipose | 100% | 2926.93 | 1204 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 3573.77 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3893.66 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 4.77 | 1 / 1 |
blood vessel | 100% | 2901.01 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 99% | 4864.47 | 922 / 929 | 0% | 0 | 0 / 0 |
heart | 97% | 2135.82 | 839 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 96% | 8.07 | 43 / 45 |
eye | 0% | 0 | 0 / 0 | 94% | 9.58 | 75 / 80 |
lymph node | 0% | 0 | 0 / 0 | 83% | 6.40 | 24 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007165 | Biological process | signal transduction |
GO_0006886 | Biological process | intracellular protein transport |
GO_0099072 | Biological process | regulation of postsynaptic membrane neurotransmitter receptor levels |
GO_0032456 | Biological process | endocytic recycling |
GO_0001770 | Biological process | establishment of natural killer cell polarity |
GO_0016197 | Biological process | endosomal transport |
GO_0008333 | Biological process | endosome to lysosome transport |
GO_0090128 | Biological process | regulation of synapse maturation |
GO_0001772 | Cellular component | immunological synapse |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
GO_0005769 | Cellular component | early endosome |
GO_0031901 | Cellular component | early endosome membrane |
GO_0030904 | Cellular component | retromer complex |
GO_0005829 | Cellular component | cytosol |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0071203 | Cellular component | WASH complex |
GO_0005768 | Cellular component | endosome |
GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
GO_0035091 | Molecular function | phosphatidylinositol binding |
GO_0005515 | Molecular function | protein binding |
Gene name | SNX27 |
Protein name | Sorting nexin 27 Sorting nexin-27 |
Synonyms | KIAA0488 My014 |
Description | FUNCTION: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. . |
Accessions | ENST00000368838.2 A0A2R8Y871 ENST00000642376.1 Q96L92 ENST00000642349.1 A0A2R8Y8A7 ENST00000482791.2 ENST00000458013.7 [Q96L92-1] H7C603 ENST00000368841.7 ENST00000642479.1 A0A2R8Y3S6 ENST00000368843.8 [Q96L92-3] A0A2R8YD75 A0A5H1ZRP6 |