SNX27 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006886Biological processintracellular protein transport
GO_0099072Biological processregulation of postsynaptic membrane neurotransmitter receptor levels
GO_0032456Biological processendocytic recycling
GO_0001770Biological processestablishment of natural killer cell polarity
GO_0016197Biological processendosomal transport
GO_0008333Biological processendosome to lysosome transport
GO_0090128Biological processregulation of synapse maturation
GO_0001772Cellular componentimmunological synapse
GO_0098978Cellular componentglutamatergic synapse
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0071203Cellular componentWASH complex
GO_0005768Cellular componentendosome
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNX27
Protein nameSorting nexin 27
Sorting nexin-27
SynonymsKIAA0488
My014
DescriptionFUNCTION: Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes. .

AccessionsENST00000368838.2
A0A2R8Y871
ENST00000642376.1
Q96L92
ENST00000642349.1
A0A2R8Y8A7
ENST00000482791.2
ENST00000458013.7 [Q96L92-1]
H7C603
ENST00000368841.7
ENST00000642479.1
A0A2R8Y3S6
ENST00000368843.8 [Q96L92-3]
A0A2R8YD75
A0A5H1ZRP6