TRIM55 | OmnibusX

Name	Number of supported studies	Average coverage
cardiac muscle cell	5 studies	33% ± 6%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM55 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	96%	1173.19	218 / 226	71%	31.78	289 / 406
kidney	76%	276.98	68 / 89	85%	18.40	766 / 901
muscle	100%	1838.03	802 / 803	0%	0	0 / 0
heart	97%	4139.52	835 / 861	0%	0	0 / 0
thymus	2%	3.24	12 / 653	30%	1.43	181 / 605
adrenal gland	0%	0	0 / 258	16%	1.54	37 / 230
brain	14%	34.12	370 / 2642	0%	0	0 / 705
lung	2%	7.23	9 / 578	10%	0.70	110 / 1155
uterus	2%	8.36	4 / 170	8%	4.33	38 / 459
lymph node	0%	0	0 / 0	10%	1.27	3 / 29
ovary	0%	0	0 / 180	9%	0.38	39 / 430
breast	1%	3.06	4 / 459	6%	1.08	67 / 1118
skin	6%	18.67	106 / 1809	1%	0.33	4 / 472
tonsil	0%	0	0 / 0	7%	0.26	3 / 45
prostate	4%	12.75	10 / 245	2%	0.09	9 / 502
blood vessel	4%	17.96	51 / 1335	0%	0	0 / 0
esophagus	0%	0.66	4 / 1445	2%	0.39	3 / 183
bladder	0%	0	0 / 21	2%	0.11	9 / 504
pancreas	0%	0	0 / 328	2%	0.23	3 / 178
adipose	1%	2.60	12 / 1204	0%	0	0 / 0
stomach	0%	0.52	1 / 359	1%	0.18	2 / 286
peripheral blood	1%	1.60	7 / 929	0%	0	0 / 0
spleen	0%	0.55	1 / 241	0%	0	0 / 0
intestine	0%	0.14	1 / 966	0%	0.02	1 / 527
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007165	Biological process	signal transduction
GO_0016567	Biological process	protein ubiquitination
GO_0002523	Biological process	leukocyte migration involved in inflammatory response
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_1901224	Biological process	positive regulation of non-canonical NF-kappaB signal transduction
GO_0050904	Biological process	diapedesis
GO_1905517	Biological process	macrophage migration
GO_0005874	Cellular component	microtubule
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0030674	Molecular function	protein-macromolecule adaptor activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding
GO_0008270	Molecular function	zinc ion binding

Gene name	TRIM55
Protein name	Tripartite motif-containing protein 55 (EC 2.3.2.27) (Muscle-specific RING finger protein 2) (MuRF-2) (MuRF2) (RING finger protein 29)
Synonyms	MURF2 RNF29
Description	FUNCTION: E3 ubiquitin ligase that plays an important role in regulating cardiac development and contractility, muscle growth, metabolism, and fiber-type differentiation. Acts as a critical factor that regulates cardiomyocyte size during development in concert with TRIM63 by regulating E2F1-mediated gene expression (By similarity). Plays a role in apoptosis induction in cardiomyocytes by promoting ubiquitination of the DUSP1 phosphatase. Promotes non-canonical NF-kappa-B signaling and B-cell-mediated immune responses by mediating NFKB2 'Lys-48'-linked ubiquitination and processing. In turn, NFKB2 is further processed by valosin-containing protein/VCP, an ATPase that mediates ubiquitin-dependent protein degradation by the proteasome. May play a role in preventing macrophages from producing inflammatory factors and migrating by downregulating the level of nuclear NF-kappa-B subunit RELA. Modifies also PPARG via polyubiquitination and accelerates PPARG proteasomal degradation to inhibit its activity . .
Accessions	ENST00000315962.9 [Q9BYV6-1] Q9BYV6 ENST00000353317.9 [Q9BYV6-2] ENST00000276573.11 [Q9BYV6-3] ENST00000350034.4 [Q9BYV6-4]

TRIM55 report