NRG2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0035556Biological processintracellular signal transduction
GO_0007399Biological processnervous system development
GO_0048513Biological processanimal organ development
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0008083Molecular functiongrowth factor activity
GO_0005102Molecular functionsignaling receptor binding

IV. Literature review

[source]
Gene nameNRG2
Protein nameNRG2 protein
Neuregulin 2
Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)]
SynonymsNTAK
DescriptionFUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerization with the EGF receptor.

AccessionsENST00000289422.11 [O14511-3]
Q3MI86
ENST00000340391.8 [O14511-8]
ENST00000541337.5
ENST00000358522.7 [O14511-4]
F5GZS7
ENST00000378238.5 [O14511-5]
ENST00000361474.6 [O14511-1]
ENST00000289409.8 [O14511-2]
O14511