PAG1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
mast cell	25 studies	34% ± 14%	Explore
pericyte	23 studies	47% ± 24%	Explore
macrophage	22 studies	27% ± 13%	Explore
non-classical monocyte	22 studies	41% ± 14%	Explore
CD4-positive, alpha-beta T cell	22 studies	27% ± 8%	Explore
T cell	19 studies	26% ± 11%	Explore
CD8-positive, alpha-beta T cell	17 studies	23% ± 7%	Explore
plasmacytoid dendritic cell	15 studies	23% ± 8%	Explore
microglial cell	15 studies	54% ± 18%	Explore
regulatory T cell	15 studies	23% ± 6%	Explore
monocyte	12 studies	31% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	28% ± 9%	Explore
mucosal invariant T cell	11 studies	22% ± 5%	Explore
myeloid cell	11 studies	27% ± 10%	Explore
fibroblast	11 studies	29% ± 19%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	24% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	24% ± 11%	Explore
astrocyte	10 studies	27% ± 11%	Explore
oligodendrocyte precursor cell	10 studies	35% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	23% ± 8%	Explore
GABAergic neuron	9 studies	29% ± 17%	Explore
oligodendrocyte	9 studies	24% ± 10%	Explore
classical monocyte	8 studies	23% ± 9%	Explore
B cell	7 studies	23% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 4%	Explore
alveolar macrophage	7 studies	44% ± 13%	Explore
glutamatergic neuron	6 studies	43% ± 20%	Explore
epithelial cell	6 studies	30% ± 13%	Explore
endothelial cell	6 studies	35% ± 15%	Explore
interneuron	6 studies	35% ± 21%	Explore
smooth muscle cell	6 studies	27% ± 13%	Explore
retina horizontal cell	6 studies	27% ± 11%	Explore
leukocyte	6 studies	37% ± 18%	Explore
precursor B cell	5 studies	34% ± 15%	Explore
pro-B cell	5 studies	42% ± 11%	Explore
dendritic cell	5 studies	26% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	31% ± 12%	Explore
melanocyte	5 studies	39% ± 18%	Explore
neutrophil	4 studies	20% ± 1%	Explore
exhausted T cell	4 studies	28% ± 7%	Explore
granule cell	4 studies	35% ± 10%	Explore
retinal ganglion cell	4 studies	31% ± 7%	Explore
retinal pigment epithelial cell	4 studies	37% ± 20%	Explore
mononuclear phagocyte	4 studies	27% ± 7%	Explore
lymphocyte	4 studies	35% ± 14%	Explore
Mueller cell	4 studies	24% ± 10%	Explore
club cell	4 studies	25% ± 7%	Explore
gamma-delta T cell	4 studies	23% ± 8%	Explore
hepatic stellate cell	3 studies	40% ± 10%	Explore
conventional dendritic cell	3 studies	23% ± 9%	Explore
amacrine cell	3 studies	28% ± 9%	Explore
germinal center B cell	3 studies	26% ± 9%	Explore
CD4-positive helper T cell	3 studies	19% ± 2%	Explore
abnormal cell	3 studies	16% ± 0%	Explore
granulocyte	3 studies	38% ± 21%	Explore
enterocyte	3 studies	24% ± 7%	Explore
T follicular helper cell	3 studies	25% ± 5%	Explore
T-helper 17 cell	3 studies	21% ± 1%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	23% ± 2%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
mural cell	3 studies	38% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	14 studies	29% ± 13%	Explore
peripheral blood	5 studies	27% ± 7%	Explore
lung	4 studies	25% ± 6%	Explore
bone marrow	3 studies	20% ± 3%	Explore
intestine	3 studies	19% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	2194.31	2548 / 2642	100%	18.68	704 / 705
skin	99%	1977.50	1786 / 1809	96%	30.06	454 / 472
stomach	99%	1430.73	356 / 359	94%	11.58	269 / 286
intestine	99%	2741.25	955 / 966	90%	8.71	473 / 527
lung	100%	8175.52	578 / 578	88%	11.09	1012 / 1155
pancreas	98%	1450.91	320 / 328	85%	7.53	151 / 178
esophagus	86%	857.33	1244 / 1445	90%	11.63	165 / 183
prostate	96%	1314.40	236 / 245	79%	5.42	395 / 502
bladder	86%	1835.38	18 / 21	79%	7.40	397 / 504
thymus	94%	1095.86	614 / 653	68%	5.37	410 / 605
breast	91%	1135.50	417 / 459	68%	4.68	762 / 1118
kidney	70%	732.82	62 / 89	81%	11.26	734 / 901
liver	90%	1197.73	203 / 226	57%	5.03	233 / 406
uterus	87%	1022.22	148 / 170	57%	3.88	263 / 459
adrenal gland	69%	610.62	179 / 258	68%	13.70	157 / 230
spleen	100%	4456.17	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	8.45	1 / 1
adipose	99%	1942.88	1196 / 1204	0%	0	0 / 0
peripheral blood	99%	6543.36	918 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	95%	18.63	76 / 80
heart	94%	1258.98	806 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	21.43	26 / 29
blood vessel	88%	1168.12	1172 / 1335	0%	0	0 / 0
ovary	53%	585.28	95 / 180	35%	1.70	149 / 430
tonsil	0%	0	0 / 0	76%	5.87	34 / 45
muscle	29%	201.02	229 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007165	Biological process	signal transduction
GO_0002250	Biological process	adaptive immune response
GO_0050868	Biological process	negative regulation of T cell activation
GO_0035556	Biological process	intracellular signal transduction
GO_0050863	Biological process	regulation of T cell activation
GO_0045121	Cellular component	membrane raft
GO_0005886	Cellular component	plasma membrane
GO_0042169	Molecular function	SH2 domain binding
GO_0035591	Molecular function	signaling adaptor activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PAG1
Protein name	Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (Csk-binding protein) (Transmembrane adapter protein PAG) (Transmembrane phosphoprotein Cbp)
Synonyms	CBP PAG
Description	FUNCTION: Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins. May be involved in cell adhesion signaling. .
Accessions	Q9NWQ8 ENST00000220597.4

PAG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review