CLIC3 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	39 studies	51% ± 19%	Explore
plasmacytoid dendritic cell	23 studies	67% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	44% ± 19%	Explore
mature NK T cell	16 studies	36% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	61% ± 18%	Explore
gamma-delta T cell	11 studies	22% ± 3%	Explore
type I pneumocyte	10 studies	62% ± 25%	Explore
type II pneumocyte	7 studies	37% ± 21%	Explore
CD8-positive, alpha-beta T cell	6 studies	33% ± 9%	Explore
mesothelial cell	6 studies	39% ± 13%	Explore
epithelial cell	6 studies	34% ± 10%	Explore
endothelial cell of artery	6 studies	20% ± 4%	Explore
T cell	5 studies	23% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	26% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	20% ± 3%	Explore
innate lymphoid cell	4 studies	38% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	18% ± 1%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	28% ± 8%	Explore
squamous epithelial cell	3 studies	57% ± 10%	Explore
extravillous trophoblast	3 studies	86% ± 6%	Explore
placental villous trophoblast	3 studies	82% ± 10%	Explore
club cell	3 studies	28% ± 11%	Explore
basal cell	3 studies	26% ± 8%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	5 studies	17% ± 2%	Explore
lung	4 studies	20% ± 5%	Explore
placenta	3 studies	60% ± 29%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	6199.01	650 / 653	97%	479.92	586 / 605
lung	94%	1837.11	545 / 578	68%	42.79	780 / 1155
esophagus	40%	4834.62	578 / 1445	68%	86.70	125 / 183
ureter	0%	0	0 / 0	100%	150.33	1 / 1
skin	75%	3846.48	1360 / 1809	13%	7.03	59 / 472
tonsil	0%	0	0 / 0	84%	72.75	38 / 45
pancreas	1%	4.78	2 / 328	79%	98.31	141 / 178
ovary	0%	0	0 / 180	79%	51.16	341 / 430
uterus	4%	148.00	7 / 170	74%	88.71	340 / 459
bladder	0%	0	0 / 21	69%	133.28	348 / 504
stomach	8%	58.58	28 / 359	55%	24.05	156 / 286
intestine	0%	1.55	3 / 966	57%	37.81	303 / 527
peripheral blood	45%	631.85	417 / 929	0%	0	0 / 0
spleen	36%	243.32	86 / 241	0%	0	0 / 0
breast	0%	2.51	2 / 459	35%	15.62	391 / 1118
lymph node	0%	0	0 / 0	24%	5.18	7 / 29
adipose	16%	153.84	197 / 1204	0%	0	0 / 0
prostate	5%	30.95	13 / 245	8%	1.73	40 / 502
kidney	0%	0	0 / 89	12%	3.36	112 / 901
heart	10%	61.77	83 / 861	0%	0	0 / 0
liver	0%	0	0 / 226	6%	3.23	26 / 406
blood vessel	6%	41.09	85 / 1335	0%	0	0 / 0
adrenal gland	0%	6.30	1 / 258	0%	0	0 / 230
brain	0%	0.41	1 / 2642	0%	0.05	2 / 705
muscle	0%	1.95	2 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0