TRIM63 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIM63 at tissue level.

III. Associated gene sets

GO_0014732Biological processskeletal muscle atrophy
GO_0007165Biological processsignal transduction
GO_0045820Biological processnegative regulation of glycolytic process
GO_0016567Biological processprotein ubiquitination
GO_0051384Biological processresponse to glucocorticoid
GO_0014878Biological processresponse to electrical stimulus involved in regulation of muscle adaptation
GO_0006936Biological processmuscle contraction
GO_0070555Biological processresponse to interleukin-1
GO_0010614Biological processnegative regulation of cardiac muscle hypertrophy
GO_0031430Cellular componentM band
GO_0030018Cellular componentZ disc
GO_0005874Cellular componentmicrotubule
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0031432Molecular functiontitin binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameTRIM63
Protein nameE3 ubiquitin-protein ligase TRIM63 (EC 2.3.2.27) (Iris RING finger protein) (Muscle-specific RING finger protein 1) (MuRF-1) (MuRF1) (RING finger protein 28) (RING-type E3 ubiquitin transferase TRIM63) (Striated muscle RING zinc finger protein) (Tripartite motif-containing protein 63)
SynonymsRNF28
MURF1
SMRZ
IRF
DescriptionFUNCTION: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. .

AccessionsENST00000374272.4 [Q969Q1-1]
Q969Q1