STK24 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0009267Biological processcellular response to starvation
GO_0048679Biological processregulation of axon regeneration
GO_0034599Biological processcellular response to oxidative stress
GO_0048680Biological processpositive regulation of axon regeneration
GO_0097194Biological processexecution phase of apoptosis
GO_0030336Biological processnegative regulation of cell migration
GO_0006468Biological processprotein phosphorylation
GO_0008631Biological processintrinsic apoptotic signaling pathway in response to oxidative stress
GO_0046777Biological processprotein autophosphorylation
GO_0005730Cellular componentnucleolus
GO_0090443Cellular componentFAR/SIN/STRIPAK complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0045296Molecular functioncadherin binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSTK24
Protein nameAlternative protein STK24
non-specific serine/threonine protein kinase (EC 2.7.11.1)
Serine/threonine kinase 24
Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]
SynonymsHEL-S-95
hCG_27759
MST3
STK3
DescriptionFUNCTION: Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation . Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. .

AccessionsENST00000418038.5
ENST00000376554.8
ENST00000397517.6
H0Y630
ENST00000539966.6 [Q9Y6E0-2]
Q6P0Y1
Q9Y6E0
B4DR80
ENST00000376547.7 [Q9Y6E0-1]
L8E7H5
Q5JV99
Q5U0E6
Q5JV98
Q6FG81
ENST00000444574.1