AKAP9 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	47 studies	36% ± 15%	Explore
fibroblast	40 studies	37% ± 13%	Explore
B cell	37 studies	31% ± 9%	Explore
natural killer cell	35 studies	30% ± 8%	Explore
T cell	32 studies	29% ± 11%	Explore
pericyte	32 studies	32% ± 10%	Explore
macrophage	31 studies	31% ± 14%	Explore
smooth muscle cell	30 studies	30% ± 10%	Explore
CD4-positive, alpha-beta T cell	28 studies	27% ± 8%	Explore
CD8-positive, alpha-beta T cell	28 studies	29% ± 7%	Explore
mast cell	24 studies	30% ± 12%	Explore
conventional dendritic cell	23 studies	27% ± 13%	Explore
astrocyte	22 studies	45% ± 19%	Explore
endothelial cell of lymphatic vessel	21 studies	37% ± 13%	Explore
epithelial cell	21 studies	47% ± 21%	Explore
regulatory T cell	21 studies	29% ± 7%	Explore
ciliated cell	20 studies	81% ± 11%	Explore
basal cell	20 studies	43% ± 19%	Explore
memory B cell	19 studies	28% ± 7%	Explore
plasmacytoid dendritic cell	19 studies	43% ± 15%	Explore
naive B cell	19 studies	28% ± 7%	Explore
microglial cell	18 studies	42% ± 16%	Explore
plasma cell	17 studies	38% ± 15%	Explore
classical monocyte	17 studies	26% ± 11%	Explore
oligodendrocyte precursor cell	17 studies	45% ± 17%	Explore
monocyte	16 studies	29% ± 13%	Explore
oligodendrocyte	16 studies	46% ± 15%	Explore
mature NK T cell	16 studies	30% ± 7%	Explore
gamma-delta T cell	16 studies	34% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	29% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	28% ± 8%	Explore
non-classical monocyte	15 studies	26% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	33% ± 9%	Explore
capillary endothelial cell	15 studies	26% ± 7%	Explore
connective tissue cell	14 studies	33% ± 10%	Explore
myofibroblast cell	14 studies	33% ± 7%	Explore
mucosal invariant T cell	14 studies	29% ± 6%	Explore
dendritic cell	13 studies	36% ± 18%	Explore
glutamatergic neuron	13 studies	60% ± 22%	Explore
vein endothelial cell	13 studies	27% ± 8%	Explore
type I pneumocyte	12 studies	53% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	29% ± 8%	Explore
myeloid cell	12 studies	30% ± 12%	Explore
type II pneumocyte	11 studies	44% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	34% ± 5%	Explore
club cell	11 studies	42% ± 13%	Explore
GABAergic neuron	11 studies	61% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	36% ± 10%	Explore
plasmablast	10 studies	37% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	28% ± 6%	Explore
leukocyte	10 studies	39% ± 13%	Explore
neuron	10 studies	59% ± 18%	Explore
endothelial cell of artery	10 studies	26% ± 4%	Explore
goblet cell	10 studies	50% ± 17%	Explore
mesothelial cell	10 studies	47% ± 9%	Explore
endothelial cell of vascular tree	10 studies	29% ± 10%	Explore
adipocyte	10 studies	51% ± 14%	Explore
secretory cell	9 studies	38% ± 17%	Explore
progenitor cell	9 studies	37% ± 11%	Explore
abnormal cell	9 studies	39% ± 13%	Explore
retinal cone cell	9 studies	94% ± 6%	Explore
retinal rod cell	9 studies	82% ± 12%	Explore
alveolar macrophage	8 studies	31% ± 13%	Explore
respiratory goblet cell	8 studies	48% ± 15%	Explore
renal alpha-intercalated cell	8 studies	41% ± 11%	Explore
amacrine cell	8 studies	54% ± 11%	Explore
retinal ganglion cell	8 studies	53% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	22% ± 8%	Explore
kidney loop of Henle epithelial cell	7 studies	38% ± 13%	Explore
interneuron	7 studies	71% ± 15%	Explore
T follicular helper cell	7 studies	24% ± 5%	Explore
ionocyte	6 studies	48% ± 14%	Explore
mononuclear phagocyte	6 studies	30% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	6 studies	36% ± 8%	Explore
IgG plasma cell	6 studies	26% ± 7%	Explore
hematopoietic stem cell	6 studies	30% ± 9%	Explore
precursor B cell	6 studies	30% ± 10%	Explore
retina horizontal cell	6 studies	60% ± 9%	Explore
mucus secreting cell	6 studies	40% ± 15%	Explore
Mueller cell	6 studies	41% ± 14%	Explore
innate lymphoid cell	6 studies	33% ± 7%	Explore
hematopoietic precursor cell	5 studies	36% ± 13%	Explore
enterocyte	5 studies	39% ± 8%	Explore
enteroendocrine cell	5 studies	41% ± 15%	Explore
IgA plasma cell	5 studies	31% ± 14%	Explore
retinal bipolar neuron	5 studies	50% ± 12%	Explore
glial cell	5 studies	35% ± 10%	Explore
pro-B cell	5 studies	35% ± 4%	Explore
brush cell	5 studies	51% ± 12%	Explore
adventitial cell	5 studies	29% ± 10%	Explore
cardiac muscle cell	5 studies	63% ± 12%	Explore
lymphocyte	5 studies	45% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	34% ± 9%	Explore
myoepithelial cell	5 studies	41% ± 15%	Explore
hepatocyte	5 studies	55% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	28% ± 7%	Explore
deuterosomal cell	4 studies	64% ± 4%	Explore
duct epithelial cell	4 studies	45% ± 21%	Explore
squamous epithelial cell	4 studies	52% ± 19%	Explore
pancreatic A cell	4 studies	56% ± 24%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	25% ± 7%	Explore
podocyte	4 studies	40% ± 11%	Explore
epithelial cell of proximal tubule	4 studies	34% ± 12%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	46% ± 15%	Explore
granule cell	4 studies	53% ± 6%	Explore
immature B cell	4 studies	28% ± 3%	Explore
retinal pigment epithelial cell	4 studies	56% ± 16%	Explore
OFF-bipolar cell	4 studies	45% ± 10%	Explore
ON-bipolar cell	4 studies	43% ± 13%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	45% ± 10%	Explore
muscle cell	4 studies	39% ± 27%	Explore
keratinocyte	4 studies	27% ± 11%	Explore
double negative thymocyte	4 studies	41% ± 15%	Explore
renal principal cell	4 studies	39% ± 6%	Explore
pancreatic D cell	3 studies	59% ± 31%	Explore
type B pancreatic cell	3 studies	70% ± 16%	Explore
exhausted T cell	3 studies	37% ± 15%	Explore
glomerular endothelial cell	3 studies	33% ± 9%	Explore
parietal epithelial cell	3 studies	43% ± 13%	Explore
intestinal crypt stem cell	3 studies	25% ± 6%	Explore
neural crest cell	3 studies	27% ± 6%	Explore
transit amplifying cell	3 studies	51% ± 34%	Explore
GABAergic interneuron	3 studies	63% ± 11%	Explore
placental villous trophoblast	3 studies	37% ± 6%	Explore
serous secreting cell	3 studies	28% ± 6%	Explore
GABAergic amacrine cell	3 studies	60% ± 7%	Explore
glycinergic amacrine cell	3 studies	51% ± 5%	Explore
rod bipolar cell	3 studies	60% ± 7%	Explore
erythroblast	3 studies	43% ± 10%	Explore
acinar cell	3 studies	42% ± 23%	Explore
CD4-positive helper T cell	3 studies	34% ± 6%	Explore
pancreatic ductal cell	3 studies	54% ± 24%	Explore
neural progenitor cell	3 studies	40% ± 5%	Explore
ependymal cell	3 studies	70% ± 8%	Explore
granulocyte	3 studies	29% ± 9%	Explore
chondrocyte	3 studies	56% ± 17%	Explore
group 3 innate lymphoid cell	3 studies	46% ± 12%	Explore
Schwann cell	3 studies	42% ± 13%	Explore
melanocyte	3 studies	44% ± 24%	Explore
T-helper 17 cell	3 studies	30% ± 5%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	26% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	25% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	25% ± 6%	Explore
mural cell	3 studies	50% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	21 studies	50% ± 20%	Explore
lung	19 studies	39% ± 11%	Explore
peripheral blood	16 studies	29% ± 12%	Explore
eye	11 studies	59% ± 20%	Explore
intestine	10 studies	30% ± 11%	Explore
kidney	9 studies	32% ± 9%	Explore
liver	6 studies	41% ± 15%	Explore
heart	5 studies	43% ± 11%	Explore
lymph node	5 studies	29% ± 10%	Explore
breast	5 studies	30% ± 6%	Explore
pancreas	4 studies	52% ± 26%	Explore
bone marrow	4 studies	26% ± 6%	Explore
uterus	4 studies	41% ± 16%	Explore
adipose	4 studies	47% ± 17%	Explore
placenta	3 studies	25% ± 5%	Explore
esophagus	3 studies	37% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	5190.28	1445 / 1445	100%	35.51	183 / 183
prostate	100%	5706.57	245 / 245	99%	19.93	498 / 502
breast	100%	6664.71	459 / 459	99%	30.63	1108 / 1118
lung	100%	5958.05	578 / 578	98%	15.66	1136 / 1155
thymus	100%	6560.76	653 / 653	98%	17.26	592 / 605
pancreas	100%	4844.50	328 / 328	98%	14.90	174 / 178
stomach	100%	5236.54	359 / 359	97%	17.39	276 / 286
intestine	100%	6587.99	966 / 966	96%	13.48	504 / 527
bladder	100%	4443.43	21 / 21	96%	10.32	482 / 504
ovary	100%	7982.31	180 / 180	96%	8.02	411 / 430
kidney	100%	3961.55	89 / 89	95%	14.12	855 / 901
uterus	100%	5747.95	170 / 170	94%	10.19	431 / 459
brain	97%	3293.05	2557 / 2642	97%	12.22	682 / 705
adrenal gland	100%	6066.33	258 / 258	93%	11.04	213 / 230
skin	100%	6134.97	1809 / 1809	90%	15.18	425 / 472
liver	100%	4507.82	226 / 226	85%	9.35	346 / 406
adipose	100%	5301.49	1204 / 1204	0%	0	0 / 0
spleen	100%	4813.88	241 / 241	0%	0	0 / 0
blood vessel	100%	4313.32	1333 / 1335	0%	0	0 / 0
muscle	100%	5396.46	800 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	11.34	43 / 45
heart	95%	3012.21	817 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	79%	7.27	23 / 29
peripheral blood	53%	1698.79	494 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	51%	5.41	41 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0060307	Biological process	regulation of ventricular cardiac muscle cell membrane repolarization
GO_0098909	Biological process	regulation of cardiac muscle cell action potential involved in regulation of contraction
GO_0051602	Biological process	response to electrical stimulus
GO_0007165	Biological process	signal transduction
GO_0033138	Biological process	positive regulation of peptidyl-serine phosphorylation
GO_1901018	Biological process	positive regulation of potassium ion transmembrane transporter activity
GO_0007020	Biological process	microtubule nucleation
GO_0031116	Biological process	positive regulation of microtubule polymerization
GO_0051661	Biological process	maintenance of centrosome location
GO_1903358	Biological process	regulation of Golgi organization
GO_0060306	Biological process	regulation of membrane repolarization
GO_0071320	Biological process	cellular response to cAMP
GO_0007268	Biological process	chemical synaptic transmission
GO_0086091	Biological process	regulation of heart rate by cardiac conduction
GO_0031503	Biological process	protein-containing complex localization
GO_0005795	Cellular component	Golgi stack
GO_0098978	Cellular component	glutamatergic synapse
GO_0005801	Cellular component	cis-Golgi network
GO_0005856	Cellular component	cytoskeleton
GO_0097060	Cellular component	synaptic membrane
GO_0005813	Cellular component	centrosome
GO_0034705	Cellular component	potassium channel complex
GO_0005794	Cellular component	Golgi apparatus
GO_0043025	Cellular component	neuronal cell body
GO_0099147	Cellular component	extrinsic component of postsynaptic density membrane
GO_0005829	Cellular component	cytosol
GO_0043231	Cellular component	intracellular membrane-bounded organelle
GO_0044307	Cellular component	dendritic branch
GO_0008076	Cellular component	voltage-gated potassium channel complex
GO_0003677	Molecular function	DNA binding
GO_0034237	Molecular function	protein kinase A regulatory subunit binding
GO_0060090	Molecular function	molecular adaptor activity
GO_0005102	Molecular function	signaling receptor binding
GO_0015459	Molecular function	potassium channel regulator activity
GO_0044325	Molecular function	transmembrane transporter binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	AKAP9
Protein name	A-kinase anchor protein 9 (AKAP-9) (A-kinase anchor protein 350 kDa) (AKAP 350) (hgAKAP 350) (A-kinase anchor protein 450 kDa) (AKAP 450) (AKAP 120-like protein) (Centrosome- and Golgi-localized PKN-associated protein) (CG-NAP) (Protein hyperion) (Protein kinase A-anchoring protein 9) (PRKA9) (Protein yotiao) A-kinase anchoring protein 9 A kinase (PRKA) anchor protein (Yotiao) 9 A kinase (PRKA) anchor protein (Yotiao) 9, isoform CRA_c (AKAP9 protein)
Synonyms	tcag7.318 hCG_1812018 AKAP350 AKAP450 KIAA0803
Description	FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus . Required for microtubule nucleation at the cis-side of the Golgi apparatus . Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase . In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement . In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery . .; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. .
Accessions	ENST00000679448.1 A0A7P0Z4Q5 A0A7P0TAX3 A0A2R8Y590 A0A7P0TBI4 A0A7P0TBH8 ENST00000680952.1 ENST00000680181.1 ENST00000681216.1 A0A7P0TAA2 Q99996 ENST00000394534.7 A0A7P0T9E2 Q6PJH3 ENST00000356239.8 [Q99996-2] A0A7P0T928 A0A7P0T939 ENST00000486313.2 A0A0A0MRF6 A0A7P0T8N5 A4D1E4 ENST00000680766.1 [Q99996-3] A0A7P0T9A9 ENST00000680534.1 A0A7P0Z4N5 ENST00000679457.1 A0A7P0TAJ1 A0A7P0TAD6 ENST00000680365.1 ENST00000359028.7 ENST00000680072.1 ENST00000674381.2 A0A6I8PUD8 ENST00000679554.1 ENST00000679821.1 H7BYL6 A0A7P0T8Z8 A0A7P0TB09 ENST00000680513.1 ENST00000681412.1 ENST00000679521.1 ENST00000491695.2 ENST00000681722.1

AKAP9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review