Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 17 studies | 57% ± 24% | |
endothelial cell | 17 studies | 29% ± 11% | |
oligodendrocyte precursor cell | 14 studies | 71% ± 20% | |
fibroblast | 10 studies | 32% ± 9% | |
glutamatergic neuron | 9 studies | 47% ± 24% | |
GABAergic neuron | 7 studies | 53% ± 17% | |
macrophage | 7 studies | 29% ± 8% | |
adipocyte | 7 studies | 25% ± 9% | |
interneuron | 6 studies | 40% ± 14% | |
mast cell | 6 studies | 23% ± 13% | |
endothelial cell of lymphatic vessel | 6 studies | 27% ± 7% | |
epithelial cell | 5 studies | 27% ± 13% | |
microglial cell | 5 studies | 32% ± 16% | |
Mueller cell | 5 studies | 32% ± 10% | |
type I pneumocyte | 5 studies | 25% ± 3% | |
type II pneumocyte | 5 studies | 39% ± 6% | |
neuron | 4 studies | 27% ± 9% | |
cardiac muscle cell | 4 studies | 20% ± 4% | |
oligodendrocyte | 4 studies | 32% ± 19% | |
club cell | 4 studies | 38% ± 12% | |
differentiation-committed oligodendrocyte precursor | 3 studies | 56% ± 2% | |
GABAergic interneuron | 3 studies | 29% ± 5% | |
pericyte | 3 studies | 33% ± 16% | |
progenitor cell | 3 studies | 37% ± 10% | |
myeloid cell | 3 studies | 21% ± 4% | |
endothelial cell of vascular tree | 3 studies | 33% ± 15% | |
retinal pigment epithelial cell | 3 studies | 38% ± 10% | |
ependymal cell | 3 studies | 47% ± 8% | |
capillary endothelial cell | 3 studies | 34% ± 10% | |
respiratory goblet cell | 3 studies | 43% ± 20% | |
basal cell | 3 studies | 25% ± 8% | |
smooth muscle cell | 3 studies | 16% ± 1% | |
mucus secreting cell | 3 studies | 29% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2229.01 | 2639 / 2642 | 100% | 45.31 | 703 / 705 |
prostate | 100% | 2151.33 | 245 / 245 | 99% | 16.81 | 499 / 502 |
esophagus | 100% | 972.29 | 1441 / 1445 | 95% | 5.81 | 174 / 183 |
breast | 100% | 1485.08 | 459 / 459 | 94% | 8.41 | 1050 / 1118 |
skin | 100% | 1042.76 | 1806 / 1809 | 89% | 11.96 | 419 / 472 |
lung | 100% | 1493.52 | 577 / 578 | 87% | 5.31 | 1008 / 1155 |
intestine | 99% | 944.42 | 960 / 966 | 81% | 3.42 | 429 / 527 |
stomach | 99% | 702.47 | 356 / 359 | 80% | 3.86 | 229 / 286 |
uterus | 100% | 1742.94 | 170 / 170 | 73% | 3.90 | 335 / 459 |
thymus | 100% | 1148.12 | 652 / 653 | 70% | 3.03 | 424 / 605 |
kidney | 99% | 759.39 | 88 / 89 | 68% | 3.06 | 617 / 901 |
bladder | 100% | 905.86 | 21 / 21 | 65% | 2.81 | 328 / 504 |
ovary | 100% | 1107.74 | 180 / 180 | 62% | 2.51 | 267 / 430 |
adrenal gland | 97% | 954.28 | 249 / 258 | 58% | 2.31 | 134 / 230 |
pancreas | 69% | 254.08 | 226 / 328 | 79% | 2.94 | 140 / 178 |
adipose | 100% | 1287.58 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 99% | 754.57 | 1322 / 1335 | 0% | 0 | 0 / 0 |
muscle | 95% | 522.19 | 764 / 803 | 0% | 0 | 0 / 0 |
heart | 92% | 537.84 | 790 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 76% | 3.43 | 34 / 45 |
spleen | 54% | 202.00 | 130 / 241 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 33% | 0.94 | 26 / 80 |
liver | 1% | 2.34 | 2 / 226 | 8% | 0.26 | 33 / 406 |
lymph node | 0% | 0 | 0 / 0 | 3% | 0.07 | 1 / 29 |
peripheral blood | 0% | 0.87 | 2 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0045198 | Biological process | establishment of epithelial cell apical/basal polarity |
GO_1900242 | Biological process | regulation of synaptic vesicle endocytosis |
GO_0031175 | Biological process | neuron projection development |
GO_0007165 | Biological process | signal transduction |
GO_0048488 | Biological process | synaptic vesicle endocytosis |
GO_0051966 | Biological process | regulation of synaptic transmission, glutamatergic |
GO_1901799 | Biological process | negative regulation of proteasomal protein catabolic process |
GO_0048667 | Biological process | cell morphogenesis involved in neuron differentiation |
GO_0030182 | Biological process | neuron differentiation |
GO_0030036 | Biological process | actin cytoskeleton organization |
GO_0006930 | Biological process | substrate-dependent cell migration, cell extension |
GO_0035023 | Biological process | regulation of Rho protein signal transduction |
GO_0099149 | Biological process | regulation of postsynaptic neurotransmitter receptor internalization |
GO_0034329 | Biological process | cell junction assembly |
GO_0030100 | Biological process | regulation of endocytosis |
GO_0098880 | Biological process | maintenance of postsynaptic specialization structure |
GO_0021707 | Biological process | cerebellar granule cell differentiation |
GO_0021895 | Biological process | cerebral cortex neuron differentiation |
GO_0007399 | Biological process | nervous system development |
GO_0007411 | Biological process | axon guidance |
GO_0098978 | Cellular component | glutamatergic synapse |
GO_0043197 | Cellular component | dendritic spine |
GO_0043195 | Cellular component | terminal bouton |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005737 | Cellular component | cytoplasm |
GO_0005543 | Molecular function | phospholipid binding |
GO_0003779 | Molecular function | actin binding |
GO_0005096 | Molecular function | GTPase activator activity |
GO_0035255 | Molecular function | ionotropic glutamate receptor binding |
Gene name | OPHN1 |
Protein name | Oligophrenin 1 Oligophrenin-1 |
Synonyms | |
Description | FUNCTION: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). . |
Accessions | A0A7P0Z4E9 ENST00000679822.1 ENST00000467444.1 ENST00000680804.1 A0A7P0T8V5 ENST00000681408.1 O60890 A0A7P0T9W4 ENST00000355520.6 [O60890-1] ENST00000679748.1 A0A7P0T9G2 A0A7P0TBB6 ENST00000680612.1 A0A7P0TBH4 Q7Z2H1 ENST00000491714.2 |