RANBP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	30 studies	34% ± 14%	Explore
natural killer cell	28 studies	28% ± 14%	Explore
endothelial cell	28 studies	35% ± 17%	Explore
B cell	27 studies	29% ± 14%	Explore
CD8-positive, alpha-beta T cell	27 studies	32% ± 19%	Explore
CD4-positive, alpha-beta T cell	27 studies	32% ± 19%	Explore
T cell	25 studies	32% ± 16%	Explore
pericyte	23 studies	33% ± 14%	Explore
smooth muscle cell	22 studies	34% ± 13%	Explore
conventional dendritic cell	21 studies	33% ± 17%	Explore
macrophage	20 studies	26% ± 11%	Explore
regulatory T cell	18 studies	31% ± 12%	Explore
basal cell	17 studies	35% ± 17%	Explore
epithelial cell	17 studies	42% ± 22%	Explore
endothelial cell of lymphatic vessel	16 studies	35% ± 13%	Explore
connective tissue cell	15 studies	41% ± 18%	Explore
memory B cell	15 studies	23% ± 9%	Explore
plasmacytoid dendritic cell	15 studies	26% ± 10%	Explore
gamma-delta T cell	14 studies	28% ± 15%	Explore
ciliated cell	13 studies	37% ± 18%	Explore
naive B cell	13 studies	20% ± 6%	Explore
myofibroblast cell	13 studies	37% ± 15%	Explore
mast cell	12 studies	22% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	23% ± 5%	Explore
mature NK T cell	12 studies	23% ± 5%	Explore
capillary endothelial cell	12 studies	29% ± 10%	Explore
monocyte	12 studies	27% ± 9%	Explore
classical monocyte	11 studies	24% ± 11%	Explore
vein endothelial cell	11 studies	32% ± 13%	Explore
endothelial cell of vascular tree	11 studies	33% ± 9%	Explore
plasma cell	10 studies	34% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	26% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	22% ± 4%	Explore
abnormal cell	10 studies	34% ± 14%	Explore
endothelial cell of artery	10 studies	27% ± 9%	Explore
myeloid cell	10 studies	29% ± 16%	Explore
non-classical monocyte	9 studies	29% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	27% ± 5%	Explore
dendritic cell	9 studies	42% ± 25%	Explore
mucosal invariant T cell	9 studies	22% ± 2%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	28% ± 9%	Explore
progenitor cell	8 studies	56% ± 15%	Explore
plasmablast	7 studies	58% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	36% ± 19%	Explore
goblet cell	7 studies	31% ± 14%	Explore
innate lymphoid cell	7 studies	24% ± 3%	Explore
T follicular helper cell	7 studies	24% ± 4%	Explore
hematopoietic precursor cell	6 studies	47% ± 25%	Explore
intestinal crypt stem cell	6 studies	34% ± 16%	Explore
transit amplifying cell	6 studies	50% ± 21%	Explore
neuron	6 studies	42% ± 22%	Explore
secretory cell	6 studies	29% ± 14%	Explore
leukocyte	5 studies	36% ± 16%	Explore
mononuclear phagocyte	5 studies	33% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	26% ± 6%	Explore
kidney loop of Henle epithelial cell	5 studies	24% ± 6%	Explore
enteroendocrine cell	5 studies	45% ± 21%	Explore
mesothelial cell	5 studies	54% ± 18%	Explore
erythroblast	5 studies	57% ± 20%	Explore
pro-B cell	5 studies	40% ± 9%	Explore
precursor B cell	5 studies	40% ± 14%	Explore
type II pneumocyte	5 studies	30% ± 16%	Explore
erythrocyte	5 studies	46% ± 27%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	31% ± 11%	Explore
deuterosomal cell	4 studies	54% ± 18%	Explore
exhausted T cell	4 studies	35% ± 9%	Explore
epithelial cell of proximal tubule	4 studies	27% ± 15%	Explore
hematopoietic stem cell	4 studies	36% ± 17%	Explore
club cell	4 studies	33% ± 9%	Explore
immature B cell	4 studies	35% ± 16%	Explore
type I pneumocyte	4 studies	35% ± 13%	Explore
germinal center B cell	4 studies	33% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	29% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	57% ± 18%	Explore
T-helper 17 cell	4 studies	42% ± 27%	Explore
precursor cell	3 studies	52% ± 20%	Explore
pancreatic A cell	3 studies	33% ± 12%	Explore
glomerular endothelial cell	3 studies	21% ± 3%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	56% ± 26%	Explore
enterocyte	3 studies	29% ± 14%	Explore
neural crest cell	3 studies	71% ± 18%	Explore
retinal ganglion cell	3 studies	69% ± 21%	Explore
extravillous trophoblast	3 studies	45% ± 22%	Explore
placental villous trophoblast	3 studies	55% ± 20%	Explore
common myeloid progenitor	3 studies	39% ± 13%	Explore
lymphocyte	3 studies	46% ± 11%	Explore
amacrine cell	3 studies	48% ± 18%	Explore
astrocyte	3 studies	29% ± 16%	Explore
retina horizontal cell	3 studies	36% ± 19%	Explore
alveolar macrophage	3 studies	19% ± 1%	Explore
intraepithelial lymphocyte	3 studies	34% ± 12%	Explore
Mueller cell	3 studies	28% ± 10%	Explore
muscle cell	3 studies	31% ± 19%	Explore
CD4-positive helper T cell	3 studies	24% ± 6%	Explore
myoepithelial cell	3 studies	35% ± 6%	Explore
GABAergic neuron	3 studies	22% ± 4%	Explore
glutamatergic neuron	3 studies	33% ± 8%	Explore
oligodendrocyte precursor cell	3 studies	38% ± 16%	Explore
granulocyte monocyte progenitor cell	3 studies	55% ± 28%	Explore
glial cell	3 studies	41% ± 27%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 15%	Explore
keratinocyte	3 studies	36% ± 9%	Explore
T-helper 1 cell	3 studies	39% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	39% ± 7%	Explore
progenitor cell of mammary luminal epithelium	3 studies	23% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	32% ± 15%	Explore
peripheral blood	12 studies	27% ± 9%	Explore
intestine	12 studies	29% ± 16%	Explore
liver	8 studies	28% ± 22%	Explore
kidney	7 studies	29% ± 13%	Explore
lymph node	7 studies	29% ± 15%	Explore
eye	5 studies	27% ± 13%	Explore
bone marrow	5 studies	24% ± 3%	Explore
brain	5 studies	24% ± 8%	Explore
uterus	4 studies	35% ± 15%	Explore
breast	4 studies	28% ± 2%	Explore
placenta	3 studies	42% ± 21%	Explore
ovary	3 studies	21% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2719.22	1445 / 1445	100%	83.49	183 / 183
intestine	100%	2657.37	966 / 966	100%	71.84	527 / 527
ovary	100%	2573.86	180 / 180	100%	72.35	430 / 430
skin	100%	3792.20	1809 / 1809	100%	61.54	472 / 472
stomach	100%	1891.65	359 / 359	100%	76.25	286 / 286
bladder	100%	2636.24	21 / 21	100%	74.68	503 / 504
uterus	100%	2829.91	170 / 170	100%	90.57	458 / 459
brain	100%	2407.83	2636 / 2642	100%	51.88	705 / 705
lung	100%	2389.38	576 / 578	100%	68.23	1153 / 1155
prostate	100%	2386.30	245 / 245	99%	32.82	498 / 502
breast	100%	2597.45	459 / 459	99%	47.83	1109 / 1118
thymus	100%	2234.69	653 / 653	99%	39.83	599 / 605
pancreas	100%	1321.19	328 / 328	99%	38.51	176 / 178
liver	100%	2128.93	226 / 226	98%	33.31	397 / 406
kidney	100%	2176.48	89 / 89	95%	23.93	858 / 901
adrenal gland	100%	2824.07	258 / 258	93%	30.17	214 / 230
adipose	100%	2434.51	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	103.91	29 / 29
spleen	100%	3144.15	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	76.33	45 / 45
ureter	0%	0	0 / 0	100%	40.46	1 / 1
blood vessel	100%	2263.13	1332 / 1335	0%	0	0 / 0
muscle	99%	1290.04	794 / 803	0%	0	0 / 0
heart	98%	1246.63	844 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	25.43	77 / 80
peripheral blood	86%	2706.14	803 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006913	Biological process	nucleocytoplasmic transport
GO_0007165	Biological process	signal transduction
GO_0046604	Biological process	positive regulation of mitotic centrosome separation
GO_0005635	Cellular component	nuclear envelope
GO_0005813	Cellular component	centrosome
GO_0005829	Cellular component	cytosol
GO_0005643	Cellular component	nuclear pore
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0045296	Molecular function	cadherin binding
GO_0005092	Molecular function	GDP-dissociation inhibitor activity
GO_0005515	Molecular function	protein binding
GO_0031267	Molecular function	small GTPase binding
GO_0005096	Molecular function	GTPase activator activity

IV. Literature review

[source]

Gene name	RANBP1
Protein name	RAN binding protein 1, isoform CRA_f (cDNA FLJ40340 fis, clone TESTI2032681, moderately similar to RAN-SPECIFIC GTPASE-ACTIVATING PROTEIN) Ran-specific GTPase-activating protein (Ran-binding protein 1) (RanBP1) RAN binding protein 1 RAN binding protein 1, isoform CRA_g (Testis secretory sperm-binding protein Li 221n)
Synonyms	hCG_17886
Description	FUNCTION: Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins . Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN . Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 . Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP . .
Accessions	ENST00000416427.5 C9JIC6 ENST00000421656.5 ENST00000435265.5 ENST00000448394.3 B3KUP2 C9JXG8 ENST00000331821.8 [P43487-1] C9JGV6 ENST00000418705.2 F6WQW2 P43487 ENST00000423859.5 ENST00000402752.5 [P43487-2] A0AA34QVZ7 F8WCY3 A0A140VK94 ENST00000430524.6

RANBP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review