VAC14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0099149Biological processregulation of postsynaptic neurotransmitter receptor internalization
GO_0006661Biological processphosphatidylinositol biosynthetic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0070772Cellular componentPAS complex
GO_0010008Cellular componentendosome membrane
GO_0031901Cellular componentearly endosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0098830Cellular componentpresynaptic endosome
GO_0038023Molecular functionsignaling receptor activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameVAC14
Protein nameProtein VAC14 homolog (Tax1-binding protein 2)
VAC14 component of PIKFYVE complex
SynonymsTRX
TAX1BP2
DescriptionFUNCTION: Scaffold protein component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Pentamerizes into a star-shaped structure and nucleates the assembly of the complex. The pentamer binds a single copy each of PIKFYVE and FIG4 and coordinates both PIKfyve kinase activity and FIG4 phosphatase activity, being required to maintain normal levels of phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P) . Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. .

AccessionsJ3QLC3
ENST00000261776.10 [Q08AM6-1]
ENST00000567648.1
ENST00000566416.1
ENST00000563662.2
Q08AM6
H3BUU8
ENST00000568886.5
A0A087WT26
ENST00000568548.5
ENST00000536184.6 [Q08AM6-2]
H3BN23
H3BQD9