PRKG2 | OmnibusX

Name	Number of supported studies	Average coverage
oligodendrocyte precursor cell	11 studies	32% ± 18%	Explore
GABAergic neuron	3 studies	41% ± 1%	Explore
glutamatergic neuron	3 studies	45% ± 13%	Explore
interneuron	3 studies	37% ± 15%	Explore

Name	Number of supported studies	Average coverage
brain	3 studies	30% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	95%	487.42	232 / 245	91%	8.24	459 / 502
esophagus	91%	485.85	1309 / 1445	69%	2.02	127 / 183
skin	95%	309.00	1711 / 1809	52%	13.01	247 / 472
lung	80%	170.45	462 / 578	61%	2.14	699 / 1155
brain	82%	192.83	2163 / 2642	49%	2.26	344 / 705
breast	77%	173.05	354 / 459	47%	1.16	523 / 1118
pancreas	59%	60.85	193 / 328	63%	1.79	113 / 178
intestine	93%	418.79	903 / 966	23%	0.43	120 / 527
kidney	60%	67.89	53 / 89	36%	1.55	323 / 901
bladder	48%	80.29	10 / 21	43%	1.09	215 / 504
uterus	41%	35.84	69 / 170	42%	1.16	191 / 459
eye	0%	0	0 / 0	76%	17.81	61 / 80
adipose	58%	142.65	694 / 1204	0%	0	0 / 0
heart	49%	205.39	419 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	44%	1.08	20 / 45
thymus	19%	23.04	125 / 653	18%	0.61	111 / 605
ovary	2%	1.54	4 / 180	32%	0.63	136 / 430
stomach	9%	6.73	32 / 359	24%	0.53	70 / 286
adrenal gland	1%	0.88	3 / 258	23%	1.38	52 / 230
lymph node	0%	0	0 / 0	7%	0.23	2 / 29
liver	0%	0	0 / 226	6%	0.34	25 / 406
blood vessel	6%	6.85	79 / 1335	0%	0	0 / 0
muscle	2%	1.32	14 / 803	0%	0	0 / 0
peripheral blood	1%	0.69	10 / 929	0%	0	0 / 0
spleen	1%	0.47	2 / 241	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007165	Biological process	signal transduction
GO_0032332	Biological process	positive regulation of chondrocyte differentiation
GO_1903829	Biological process	positive regulation of protein localization
GO_0006468	Biological process	protein phosphorylation
GO_0010737	Biological process	protein kinase A signaling
GO_0072659	Biological process	protein localization to plasma membrane
GO_2001226	Biological process	negative regulation of chloride transport
GO_0046146	Biological process	tetrahydrobiopterin metabolic process
GO_0016324	Cellular component	apical plasma membrane
GO_0005829	Cellular component	cytosol
GO_0031965	Cellular component	nuclear membrane
GO_0051019	Molecular function	mitogen-activated protein kinase binding
GO_0004692	Molecular function	cGMP-dependent protein kinase activity
GO_0042802	Molecular function	identical protein binding
GO_0106310	Molecular function	protein serine kinase activity
GO_0005524	Molecular function	ATP binding
GO_0004672	Molecular function	protein kinase activity
GO_0030553	Molecular function	cGMP binding

Gene name	PRKG2
Protein name	Protein kinase cGMP-dependent 2 (cDNA, FLJ79039, highly similar to cGMP-dependent protein kinase 2) cGMP-dependent protein kinase 2 (cGK 2) (cGK2) (EC 2.7.11.12) (cGMP-dependent protein kinase II) (cGKII) cGMP-dependent protein kinase (EC 2.7.11.12)
Synonyms	PRKGR2 hCG_25079
Description	FUNCTION: Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum . Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity). .
Accessions	ENST00000264399.6 [Q13237-1] Q13237 B7ZA25 A0A140VJM3 ENST00000545647.5 ENST00000395578.3 [Q13237-1] ENST00000628926.1 [Q13237-2]

PRKG2 report