FAM83D report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of FAM83D at tissue level.

III. Associated gene sets

GO_0001837Biological processepithelial to mesenchymal transition
GO_0042176Biological processregulation of protein catabolic process
GO_1902808Biological processpositive regulation of cell cycle G1/S phase transition
GO_0008283Biological processcell population proliferation
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0051310Biological processmetaphase chromosome alignment
GO_0007165Biological processsignal transduction
GO_0051301Biological processcell division
GO_1902480Biological processprotein localization to mitotic spindle
GO_0032006Biological processregulation of TOR signaling
GO_0016477Biological processcell migration
GO_0097431Cellular componentmitotic spindle pole
GO_0072686Cellular componentmitotic spindle
GO_0045171Cellular componentintercellular bridge
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005819Cellular componentspindle
GO_0019901Molecular functionprotein kinase binding
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameFAM83D
Protein nameProtein FAM83D (Spindle protein CHICA)
Chromosome 20 open reading frame 129 (Family with sequence similarity 83 member D)
SynonymsC20orf129
hCG_38062
DescriptionFUNCTION: Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC . May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade . May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 . .

AccessionsQ9H4H8
A0A087WXK8
ENST00000619850.2 [Q9H4H8-1]
ENST00000619304.4