IL36RN report

I. Expression across cell types

Insufficient scRNA-seq data for expression of IL36RN at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of IL36RN at tissue level.

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0007165Biological processsignal transduction
GO_0032689Biological processnegative regulation of type II interferon production
GO_0032700Biological processnegative regulation of interleukin-17 production
GO_0001960Biological processnegative regulation of cytokine-mediated signaling pathway
GO_0002437Biological processinflammatory response to antigenic stimulus
GO_0019732Biological processantifungal humoral response
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005737Cellular componentcytoplasm
GO_0005152Molecular functioninterleukin-1 receptor antagonist activity
GO_0005515Molecular functionprotein binding
GO_0005125Molecular functioncytokine activity
GO_0005149Molecular functioninterleukin-1 receptor binding

IV. Literature review

[source]
Gene nameIL36RN
Protein nameInterleukin 36 receptor antagonist
Interleukin-36 receptor antagonist protein (IL-36Ra) (FIL1 delta) (IL-1-related protein 3) (IL-1RP3) (Interleukin-1 HY1) (IL-1HY1) (Interleukin-1 delta) (IL-1 delta) (Interleukin-1 family member 5) (IL-1F5) (Interleukin-1 receptor antagonist homolog 1) (IL-1ra homolog 1) (Interleukin-1-like protein 1) (IL-1L1)
Interleukin-1
SynonymsIL1F5
IL1HY1
UNQ1896/PRO4342
IL1L1
IL1RP3
FIL1D
DescriptionFUNCTION: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. .

AccessionsENST00000437409.2
Q9UBH0
C9JTH1
ENST00000393200.7
ENST00000514072.1
ENST00000346807.7
ENST00000437409.1
U3KPW9