METRNL report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0097009Biological processenergy homeostasis
GO_0050873Biological processbrown fat cell differentiation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0090336Biological processpositive regulation of brown fat cell differentiation
GO_0009409Biological processresponse to cold
GO_0014850Biological processresponse to muscle activity
GO_0045444Biological processfat cell differentiation
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005179Molecular functionhormone activity
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameMETRNL
Protein nameMeteorin-like protein
METRNL protein
Meteorin-like protein (Subfatin)
Synonyms
DescriptionFUNCTION: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). .

AccessionsENST00000574053.1
I3L0R0
ENST00000571814.1 [Q641Q3-2]
ENST00000570778.5 [Q641Q3-2]
ENST00000616599.2 [Q641Q3-2]
ENST00000634158.1 [Q641Q3-2]
ENST00000633913.1 [Q641Q3-1]
ENST00000320095.12 [Q641Q3-1]
Q641Q3
Q147U6