CDK4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904628Biological processcellular response to phorbol 13-acetate 12-myristate
GO_0010468Biological processregulation of gene expression
GO_0061469Biological processregulation of type B pancreatic cell proliferation
GO_0048146Biological processpositive regulation of fibroblast proliferation
GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_0007165Biological processsignal transduction
GO_0051301Biological processcell division
GO_0010389Biological processregulation of G2/M transition of mitotic cell cycle
GO_0071353Biological processcellular response to interleukin-4
GO_1904637Biological processcellular response to ionomycin
GO_0060260Biological processregulation of transcription initiation by RNA polymerase II
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0006468Biological processprotein phosphorylation
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0051726Biological processregulation of cell cycle
GO_0000082Biological processG1/S transition of mitotic cell cycle
GO_0005730Cellular componentnucleolus
GO_0097128Cellular componentcyclin D1-CDK4 complex
GO_0005654Cellular componentnucleoplasm
GO_0097129Cellular componentcyclin D2-CDK4 complex
GO_0000307Cellular componentcyclin-dependent protein kinase holoenzyme complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005923Cellular componentbicellular tight junction
GO_0097130Cellular componentcyclin D3-CDK4 complex
GO_0000785Cellular componentchromatin
GO_0031965Cellular componentnuclear membrane
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0016538Molecular functioncyclin-dependent protein serine/threonine kinase regulator activity
GO_0005524Molecular functionATP binding
GO_0030332Molecular functioncyclin binding
GO_0005515Molecular functionprotein binding
GO_0004693Molecular functioncyclin-dependent protein serine/threonine kinase activity

IV. Literature review

[source]
Gene nameCDK4
Protein nameCyclin-dependent kinase 4
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Cyclin dependent kinase 4
cyclin-dependent kinase (EC 2.7.11.22)
SynonymshCG_40151
DescriptionFUNCTION: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. .

AccessionsF8VXD2
F8VYH9
ENST00000549606.5
ENST00000312990.10
F8VWX7
ENST00000552254.5
F8VZ51
ENST00000550419.5
ENST00000546489.5
Q96BE9
F8VYY1
ENST00000553237.5
F8VZ13
F8VTV8
ENST00000552862.1
Q6LC83
F8VZZ0
P11802
ENST00000551800.5
ENST00000552388.1
ENST00000547281.5
A0A6H0CER3
ENST00000257904.11 [P11802-1]
F8W1L8