BST1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BST1 at tissue level.

III. Associated gene sets

GO_2001044Biological processregulation of integrin-mediated signaling pathway
GO_0007165Biological processsignal transduction
GO_0002691Biological processregulation of cellular extravasation
GO_0090322Biological processregulation of superoxide metabolic process
GO_0050727Biological processregulation of inflammatory response
GO_0001952Biological processregulation of cell-matrix adhesion
GO_0090022Biological processregulation of neutrophil chemotaxis
GO_0006959Biological processhumoral immune response
GO_0050730Biological processregulation of peptidyl-tyrosine phosphorylation
GO_0050848Biological processregulation of calcium-mediated signaling
GO_0030890Biological processpositive regulation of B cell proliferation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0032956Biological processregulation of actin cytoskeleton organization
GO_0005576Cellular componentextracellular region
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0098552Cellular componentside of membrane
GO_0001931Cellular componenturopod
GO_0003953Molecular functionNAD+ nucleosidase activity
GO_0016849Molecular functionphosphorus-oxygen lyase activity
GO_0016740Molecular functiontransferase activity
GO_0061809Molecular functionNAD+ nucleotidase, cyclic ADP-ribose generating

IV. Literature review

[source]
Gene nameBST1
Protein nameADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 (EC 3.2.2.6) (ADP-ribosyl cyclase 2) (Bone marrow stromal cell antigen 1) (BST-1) (Cyclic ADP-ribose hydrolase 2) (cADPR hydrolase 2) (CD antigen CD157)
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase (EC 3.2.2.6)
Synonyms
DescriptionFUNCTION: Catalyzes both the synthesis of cyclic ADP-beta-D-ribose (cADPR) from NAD(+), and its hydrolysis to ADP-D-ribose (ADPR) . Cyclic ADPR is known to serve as an endogenous second messenger that elicits calcium release from intracellular stores, and thus regulates the mobilization of intracellular calcium (Probable). May be involved in pre-B-cell growth (Probable). .

AccessionsENST00000265016.9 [Q10588-1]
H0Y8G4
A0A386NEX7
A6NC48
H0Y984
ENST00000382346.7
ENST00000514989.1
ENST00000514445.5
Q10588
ENST00000505785.5
H0Y9Q9