CALCOCO1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030518Biological processnuclear receptor-mediated steroid hormone signaling pathway
GO_0007165Biological processsignal transduction
GO_0010628Biological processpositive regulation of gene expression
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0016055Biological processWnt signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0008013Molecular functionbeta-catenin binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0046872Molecular functionmetal ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCALCOCO1
Protein nameCalcium-binding and coiled-coil domain-containing protein 1
Calcium-binding and coiled-coil domain-containing protein 1 (Calphoglin) (Coiled-coil coactivator protein) (Sarcoma antigen NY-SAR-3)
Calcium binding and coiled-coil domain 1
Alternative protein CALCOCO1
SynonymsPP13275
UNQ2436/PRO4996
KIAA1536
DescriptionFUNCTION: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions (By similarity). In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells . .; FUNCTION: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. .

AccessionsF8VZI3
ENST00000552623.5
F8VRQ9
F8VXS2
F8W0X2
H3BRW8
F8VQE3
F8VWP8
ENST00000549688.1
ENST00000549349.5
ENST00000550804.6 [Q9P1Z2-1]
ENST00000546443.5
ENST00000546619.5
F8VPN1
ENST00000430117.6 [Q9P1Z2-4]
ENST00000549784.5
ENST00000548177.5
Q9P1Z2
F8VUB3
ENST00000548263.5 [Q9P1Z2-2]
ENST00000262059.8 [Q9P1Z2-3]
ENST00000551900.5
L8ECJ1
ENST00000549173.5