Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 40 studies | 36% ± 15% | |
| endothelial cell of lymphatic vessel | 23 studies | 41% ± 18% | |
| capillary endothelial cell | 14 studies | 39% ± 16% | |
| endothelial cell of artery | 13 studies | 40% ± 19% | |
| vein endothelial cell | 11 studies | 35% ± 20% | |
| endothelial cell of vascular tree | 9 studies | 30% ± 11% | |
| glomerular endothelial cell | 3 studies | 28% ± 4% |
Insufficient scRNA-seq data for expression of TIE1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 5737.10 | 653 / 653 | 98% | 19.30 | 591 / 605 |
| breast | 100% | 8325.96 | 459 / 459 | 97% | 14.25 | 1081 / 1118 |
| prostate | 99% | 2486.47 | 243 / 245 | 95% | 9.52 | 477 / 502 |
| lung | 100% | 7686.21 | 578 / 578 | 92% | 10.61 | 1067 / 1155 |
| adrenal gland | 99% | 1968.20 | 256 / 258 | 93% | 16.82 | 214 / 230 |
| kidney | 100% | 3127.28 | 89 / 89 | 85% | 27.40 | 764 / 901 |
| bladder | 100% | 3172.95 | 21 / 21 | 82% | 7.56 | 411 / 504 |
| intestine | 95% | 2277.50 | 913 / 966 | 83% | 7.82 | 437 / 527 |
| esophagus | 90% | 2517.57 | 1301 / 1445 | 86% | 8.08 | 157 / 183 |
| uterus | 100% | 4896.03 | 170 / 170 | 71% | 6.75 | 328 / 459 |
| brain | 70% | 1082.14 | 1861 / 2642 | 99% | 19.06 | 700 / 705 |
| stomach | 79% | 1423.08 | 285 / 359 | 86% | 9.82 | 246 / 286 |
| ovary | 66% | 1449.98 | 119 / 180 | 80% | 5.64 | 343 / 430 |
| skin | 61% | 1066.24 | 1106 / 1809 | 80% | 10.08 | 378 / 472 |
| liver | 38% | 452.12 | 85 / 226 | 90% | 9.86 | 366 / 406 |
| pancreas | 20% | 200.96 | 64 / 328 | 98% | 16.26 | 175 / 178 |
| adipose | 100% | 9327.62 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4367.47 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.06 | 1 / 1 |
| heart | 100% | 3481.36 | 858 / 861 | 0% | 0 | 0 / 0 |
| muscle | 95% | 1783.62 | 760 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 90% | 10.54 | 26 / 29 |
| blood vessel | 82% | 2048.36 | 1101 / 1335 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 82% | 6.11 | 37 / 45 |
| eye | 0% | 0 | 0 / 0 | 40% | 1.92 | 32 / 80 |
| peripheral blood | 2% | 32.16 | 23 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0007498 | Biological process | mesoderm development |
| GO_0001525 | Biological process | angiogenesis |
| GO_0007169 | Biological process | cell surface receptor protein tyrosine kinase signaling pathway |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0060836 | Biological process | lymphatic endothelial cell differentiation |
| GO_0045766 | Biological process | positive regulation of angiogenesis |
| GO_0007165 | Biological process | signal transduction |
| GO_0007275 | Biological process | multicellular organism development |
| GO_0001570 | Biological process | vasculogenesis |
| GO_0003180 | Biological process | aortic valve morphogenesis |
| GO_1901201 | Biological process | regulation of extracellular matrix assembly |
| GO_0016525 | Biological process | negative regulation of angiogenesis |
| GO_0048771 | Biological process | tissue remodeling |
| GO_0033674 | Biological process | positive regulation of kinase activity |
| GO_0060854 | Biological process | branching involved in lymph vessel morphogenesis |
| GO_0032526 | Biological process | response to retinoic acid |
| GO_0030336 | Biological process | negative regulation of cell migration |
| GO_0001936 | Biological process | regulation of endothelial cell proliferation |
| GO_0045026 | Biological process | plasma membrane fusion |
| GO_0043235 | Cellular component | receptor complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0004714 | Molecular function | transmembrane receptor protein tyrosine kinase activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TIE1 |
| Protein name | Tyrosine-protein kinase receptor Tie-1 (EC 2.7.10.1) |
| Synonyms | TIE |
| Description | FUNCTION: Transmembrane tyrosine-protein kinase that may modulate TEK/TIE2 activity and contribute to the regulation of angiogenesis. . |
| Accessions | ENST00000372476.8 [P35590-1] ENST00000538015.1 [P35590-2] P35590 |