GMFG report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	40 studies	58% ± 17%	Explore
B cell	39 studies	43% ± 16%	Explore
macrophage	37 studies	50% ± 18%	Explore
CD8-positive, alpha-beta T cell	37 studies	59% ± 20%	Explore
T cell	34 studies	55% ± 22%	Explore
CD4-positive, alpha-beta T cell	32 studies	65% ± 19%	Explore
endothelial cell	29 studies	38% ± 16%	Explore
regulatory T cell	28 studies	69% ± 16%	Explore
classical monocyte	27 studies	68% ± 21%	Explore
conventional dendritic cell	27 studies	64% ± 16%	Explore
monocyte	25 studies	59% ± 24%	Explore
non-classical monocyte	24 studies	77% ± 19%	Explore
mature NK T cell	22 studies	54% ± 15%	Explore
mast cell	20 studies	37% ± 15%	Explore
memory B cell	20 studies	39% ± 11%	Explore
dendritic cell	19 studies	58% ± 24%	Explore
endothelial cell of lymphatic vessel	19 studies	54% ± 15%	Explore
gamma-delta T cell	19 studies	53% ± 18%	Explore
naive B cell	19 studies	39% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	59% ± 18%	Explore
plasma cell	18 studies	45% ± 15%	Explore
plasmacytoid dendritic cell	18 studies	47% ± 14%	Explore
mucosal invariant T cell	16 studies	54% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	57% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	61% ± 15%	Explore
neutrophil	15 studies	55% ± 19%	Explore
myeloid cell	15 studies	51% ± 21%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	65% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	54% ± 22%	Explore
innate lymphoid cell	12 studies	48% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	62% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	57% ± 21%	Explore
capillary endothelial cell	12 studies	43% ± 14%	Explore
plasmablast	11 studies	62% ± 21%	Explore
endothelial cell of vascular tree	10 studies	31% ± 10%	Explore
platelet	9 studies	44% ± 15%	Explore
vein endothelial cell	9 studies	31% ± 10%	Explore
T follicular helper cell	9 studies	62% ± 12%	Explore
hematopoietic stem cell	9 studies	66% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	60% ± 29%	Explore
leukocyte	8 studies	49% ± 18%	Explore
pericyte	7 studies	29% ± 17%	Explore
precursor B cell	7 studies	50% ± 22%	Explore
alveolar macrophage	6 studies	56% ± 19%	Explore
CD4-positive helper T cell	6 studies	45% ± 6%	Explore
hematopoietic precursor cell	6 studies	66% ± 24%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	73% ± 28%	Explore
mononuclear phagocyte	6 studies	58% ± 27%	Explore
intermediate monocyte	6 studies	69% ± 29%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	72% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	53% ± 17%	Explore
exhausted T cell	5 studies	77% ± 16%	Explore
megakaryocyte	5 studies	71% ± 15%	Explore
pro-B cell	5 studies	71% ± 16%	Explore
T-helper 17 cell	5 studies	73% ± 16%	Explore
group 3 innate lymphoid cell	5 studies	65% ± 14%	Explore
double negative thymocyte	5 studies	81% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	56% ± 30%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	58% ± 19%	Explore
glomerular endothelial cell	4 studies	62% ± 8%	Explore
erythroblast	4 studies	28% ± 7%	Explore
lymphocyte	4 studies	48% ± 21%	Explore
immature B cell	4 studies	56% ± 19%	Explore
microglial cell	4 studies	38% ± 15%	Explore
granulocyte	4 studies	63% ± 17%	Explore
T-helper 1 cell	4 studies	77% ± 11%	Explore
monocyte-derived dendritic cell	3 studies	62% ± 34%	Explore
thymocyte	3 studies	48% ± 34%	Explore
tissue-resident macrophage	3 studies	39% ± 17%	Explore
intraepithelial lymphocyte	3 studies	59% ± 18%	Explore
endothelial cell of sinusoid	3 studies	37% ± 7%	Explore
germinal center B cell	3 studies	41% ± 2%	Explore
inflammatory macrophage	3 studies	44% ± 10%	Explore
IgG plasma cell	3 studies	28% ± 17%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	78% ± 3%	Explore
double-positive, alpha-beta thymocyte	3 studies	81% ± 9%	Explore
erythrocyte	3 studies	40% ± 12%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	65% ± 17%	Explore
lung	11 studies	38% ± 9%	Explore
bone marrow	6 studies	42% ± 16%	Explore
intestine	5 studies	30% ± 9%	Explore
kidney	5 studies	35% ± 17%	Explore
lymph node	5 studies	45% ± 11%	Explore
liver	5 studies	43% ± 16%	Explore
placenta	3 studies	28% ± 6%	Explore
thymus	3 studies	65% ± 30%	Explore
brain	3 studies	34% ± 8%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	1153.81	650 / 653	99%	120.03	601 / 605
breast	100%	1935.19	459 / 459	96%	36.89	1077 / 1118
lung	100%	3243.74	578 / 578	95%	41.54	1102 / 1155
kidney	98%	922.75	87 / 89	92%	59.85	828 / 901
bladder	90%	867.33	19 / 21	89%	39.54	448 / 504
adrenal gland	93%	612.41	241 / 258	86%	28.29	197 / 230
uterus	88%	541.29	150 / 170	90%	31.80	414 / 459
intestine	82%	909.74	793 / 966	83%	23.45	438 / 527
stomach	74%	421.20	264 / 359	86%	22.53	245 / 286
prostate	80%	522.98	197 / 245	78%	16.74	392 / 502
liver	47%	274.64	107 / 226	91%	26.19	371 / 406
brain	41%	194.93	1085 / 2642	97%	38.36	685 / 705
skin	47%	249.66	858 / 1809	90%	46.64	423 / 472
esophagus	62%	346.56	891 / 1445	63%	11.95	115 / 183
pancreas	13%	57.98	41 / 328	97%	50.42	172 / 178
adipose	100%	2275.26	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	395.35	29 / 29
peripheral blood	100%	13304.70	929 / 929	0%	0	0 / 0
spleen	100%	9060.55	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	48.91	44 / 45
ovary	24%	122.44	43 / 180	70%	13.36	299 / 430
blood vessel	63%	492.33	842 / 1335	0%	0	0 / 0
heart	55%	275.93	472 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	29%	6.25	23 / 80
muscle	8%	34.02	65 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1