CCN4 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of CCN4 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	95%	1177.57	548 / 578	91%	16.01	1046 / 1155
ovary	95%	852.08	171 / 180	72%	8.74	308 / 430
uterus	99%	1399.68	169 / 170	64%	11.86	296 / 459
kidney	100%	1241.07	89 / 89	62%	7.49	560 / 901
intestine	82%	393.42	789 / 966	74%	9.33	388 / 527
adrenal gland	100%	1388.75	258 / 258	45%	4.00	103 / 230
bladder	71%	290.14	15 / 21	67%	11.63	336 / 504
esophagus	67%	628.21	972 / 1445	70%	10.20	128 / 183
breast	37%	92.39	169 / 459	94%	24.25	1052 / 1118
prostate	99%	490.66	243 / 245	30%	1.49	149 / 502
skin	69%	1889.37	1249 / 1809	58%	5.81	276 / 472
stomach	43%	347.58	155 / 359	82%	10.19	234 / 286
pancreas	14%	50.36	47 / 328	89%	26.49	158 / 178
blood vessel	99%	871.13	1320 / 1335	0%	0	0 / 0
spleen	93%	308.07	225 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	76%	21.99	34 / 45
thymus	51%	138.37	330 / 653	18%	1.57	109 / 605
heart	63%	246.06	540 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	62%	5.46	18 / 29
adipose	61%	328.20	736 / 1204	0%	0	0 / 0
liver	35%	126.68	78 / 226	18%	1.74	74 / 406
brain	1%	1.30	22 / 2642	29%	6.26	204 / 705
eye	0%	0	0 / 0	6%	0.26	5 / 80
muscle	2%	4.72	20 / 803	0%	0	0 / 0
peripheral blood	0%	0.28	1 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0030316	Biological process	osteoclast differentiation
GO_0001649	Biological process	osteoblast differentiation
GO_0048661	Biological process	positive regulation of smooth muscle cell proliferation
GO_0007165	Biological process	signal transduction
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_0007155	Biological process	cell adhesion
GO_0045669	Biological process	positive regulation of osteoblast differentiation
GO_0014911	Biological process	positive regulation of smooth muscle cell migration
GO_0007267	Biological process	cell-cell signaling
GO_0032331	Biological process	negative regulation of chondrocyte differentiation
GO_0045597	Biological process	positive regulation of cell differentiation
GO_0001817	Biological process	regulation of cytokine production
GO_0050729	Biological process	positive regulation of inflammatory response
GO_0016055	Biological process	Wnt signaling pathway
GO_0060348	Biological process	bone development
GO_0030177	Biological process	positive regulation of Wnt signaling pathway
GO_0042593	Biological process	glucose homeostasis
GO_0090303	Biological process	positive regulation of wound healing
GO_0005615	Cellular component	extracellular space
GO_0031012	Cellular component	extracellular matrix
GO_0005829	Cellular component	cytosol
GO_0008201	Molecular function	heparin binding
GO_0005178	Molecular function	integrin binding
GO_0005515	Molecular function	protein binding

Gene name	CCN4
Protein name	CCN family member 4 (WNT1-inducible-signaling pathway protein 1) (WISP-1) (Wnt-1-induced secreted protein) Cellular communication network factor 4
Synonyms	WISP1
Description	FUNCTION: Downstream regulator in the Wnt/Frizzled-signaling pathway. Associated with cell survival. Attenuates p53-mediated apoptosis in response to DNA damage through activation of AKT kinase. Up-regulates the anti-apoptotic Bcl-X(L) protein. Adheres to skin and melanoma fibroblasts. In vitro binding to skin fibroblasts occurs through the proteoglycans, decorin and biglycan. .
Accessions	ENST00000377862.6 ENST00000220856.6 [O95388-2] ENST00000250160.11 [O95388-1] O95388 ENST00000517423.5 [O95388-4] ENST00000519433.1 [O95388-3] E5RG88

CCN4 report