IPO8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006606Biological processprotein import into nucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005635Cellular componentnuclear envelope
GO_0005515Molecular functionprotein binding
GO_0031267Molecular functionsmall GTPase binding

IV. Literature review

[source]
Gene nameIPO8
Protein nameImportin-8 (Imp8) (Ran-binding protein 8) (RanBP8)
Importin 8
SynonymsRANBP8
DescriptionFUNCTION: Involved in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter-like protein in association with the importin-beta subunit KPNB1. Acting autonomously, may serve as receptor for nuclear localization signals (NLS) and promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . In vitro mediates the nuclear import of the signal recognition particle protein SRP19 . May also be involved in cytoplasm-to-nucleus shuttling of a broad spectrum of other cargos, including Argonaute-microRNAs complexes, the JUN protein, RELA/NF-kappa-B p65 subunit, the translation initiation factor EIF4E and a set of receptor-activated mothers against decapentaplegic homolog (SMAD) transcription factors that play a critical role downstream of the large family of transforming growth factor beta and bone morphogenetic protein (BMP) cytokines (Probable). .

AccessionsF5H009
H0YH64
F5H815
ENST00000542464.1
ENST00000544829.5 [O15397-2]
ENST00000535598.1
F5H292
O15397
ENST00000545077.1
ENST00000256079.9 [O15397-1]
ENST00000543446.1
F5H2I3
ENST00000358724.4
A0A087WXH2
F5GXT5
ENST00000535989.1
ENST00000611458.4
ENST00000540979.1
F5H244