PDE9A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046069Biological processcGMP catabolic process
GO_0010613Biological processpositive regulation of cardiac muscle hypertrophy
GO_0007165Biological processsignal transduction
GO_0019933Biological processcAMP-mediated signaling
GO_0046068Biological processcGMP metabolic process
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_2000178Biological processnegative regulation of neural precursor cell proliferation
GO_0032587Cellular componentruffle membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0043204Cellular componentperikaryon
GO_0042383Cellular componentsarcolemma
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0004114Molecular function3',5'-cyclic-nucleotide phosphodiesterase activity
GO_0047555Molecular function3',5'-cyclic-GMP phosphodiesterase activity
GO_0046872Molecular functionmetal ion binding
GO_0004115Molecular function3',5'-cyclic-AMP phosphodiesterase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePDE9A
Protein namePhosphodiesterase (EC 3.1.4.-)
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (EC 3.1.4.35)
SynonymshCG_401272
DescriptionFUNCTION: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP . Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart . Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). .

AccessionsENST00000398227.7 [O76083-9]
ENST00000335440.10 [O76083-12]
A0A0S2Z475
ENST00000398234.7 [O76083-6]
ENST00000398232.7 [O76083-13]
ENST00000349112.7 [O76083-4]
ENST00000398224.3 [O76083-3]
ENST00000398236.7 [O76083-8]
ENST00000398225.7 [O76083-14]
ENST00000328862.10 [O76083-15]
ENST00000291539.11 [O76083-1]
O76083
ENST00000335512.8 [O76083-2]
A0A0S2Z4T6
ENST00000380328.6 [O76083-5]
ENST00000398229.7 [O76083-11]
A0A0S2Z4A3