BGLAP report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BGLAP at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BGLAP at tissue level.

III. Associated gene sets

GO_0033574Biological processresponse to testosterone
GO_0033280Biological processresponse to vitamin D
GO_0032869Biological processcellular response to insulin stimulus
GO_0036005Biological processresponse to macrophage colony-stimulating factor
GO_0043627Biological processresponse to estrogen
GO_0007611Biological processlearning or memory
GO_2000224Biological processregulation of testosterone biosynthetic process
GO_0071305Biological processcellular response to vitamin D
GO_0001649Biological processosteoblast differentiation
GO_0007165Biological processsignal transduction
GO_0045124Biological processregulation of bone resorption
GO_0030500Biological processregulation of bone mineralization
GO_0007155Biological processcell adhesion
GO_0014823Biological processresponse to activity
GO_0045471Biological processresponse to ethanol
GO_0071363Biological processcellular response to growth factor stimulus
GO_1903011Biological processnegative regulation of bone development
GO_0045670Biological processregulation of osteoclast differentiation
GO_0051384Biological processresponse to glucocorticoid
GO_0033594Biological processresponse to hydroxyisoflavone
GO_0032571Biological processresponse to vitamin K
GO_0030282Biological processbone mineralization
GO_0016311Biological processdephosphorylation
GO_0009629Biological processresponse to gravity
GO_0010043Biological processresponse to zinc ion
GO_0001956Biological processpositive regulation of neurotransmitter secretion
GO_0007420Biological processbrain development
GO_0001501Biological processskeletal system development
GO_0050890Biological processcognition
GO_0009612Biological processresponse to mechanical stimulus
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0048863Biological processstem cell differentiation
GO_0060348Biological processbone development
GO_0044342Biological processtype B pancreatic cell proliferation
GO_1900076Biological processregulation of cellular response to insulin stimulus
GO_0002076Biological processosteoblast development
GO_0042593Biological processglucose homeostasis
GO_0034224Biological processcellular response to zinc ion starvation
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0043204Cellular componentperikaryon
GO_0005796Cellular componentGolgi lumen
GO_0030425Cellular componentdendrite
GO_0005788Cellular componentendoplasmic reticulum lumen
GO_0005737Cellular componentcytoplasm
GO_0031982Cellular componentvesicle
GO_0008147Molecular functionstructural constituent of bone
GO_0005179Molecular functionhormone activity
GO_0005198Molecular functionstructural molecule activity
GO_0046848Molecular functionhydroxyapatite binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBGLAP
Protein nameOsteocalcin (Bone Gla protein) (BGP) (Gamma-carboxyglutamic acid-containing protein)
Synonyms
DescriptionFUNCTION: Bone protein that constitutes 1-2% of the total bone protein, and which acts as a negative regulator of bone formation . Functions to limit bone formation without impairing bone resorption or mineralization (By similarity). It binds strongly to apatite and calcium . .; FUNCTION: The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development. .

FUNCTION: The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium. .; FUNCTION: The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development. .

AccessionsP84351
ENST00000368272.5
P02818